610318-54-2 Usage
Uses
Used in Pharmaceutical Industry:
2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid is used as a pharmaceutical compound for the development of cancer treatments. It functions as a liver X receptor β agonist, which can modulate cellular processes and potentially impact cancer cell growth and survival.
Additionally, it is used as a GITR modulator, which can influence immune responses and may contribute to the effectiveness of cancer immunotherapies. The combination of these two properties in RGX-104 suggests a multifaceted approach to cancer treatment, targeting both the tumor cells and the immune system to enhance the body's natural defenses against cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 610318-54-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,0,3,1 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 610318-54:
(8*6)+(7*1)+(6*0)+(5*3)+(4*1)+(3*8)+(2*5)+(1*4)=112
112 % 10 = 2
So 610318-54-2 is a valid CAS Registry Number.
610318-54-2Relevant academic research and scientific papers
The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages
Marino Jr., Joseph P.,Kallander, Lara S.,Ma, Chun,Oh, Hye-Ja,Lee, Dennis,Gaitanopoulos, Dimitri E.,Krawiec, John A.,Parks, Derek J.,Webb, Christine L.,Ziegler, Kelly,Jaye, Michael,Thompson, Scott K.
scheme or table, p. 5617 - 5621 (2010/04/30)
The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism. SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.
