610318-97-3Relevant academic research and scientific papers
The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages
Marino Jr., Joseph P.,Kallander, Lara S.,Ma, Chun,Oh, Hye-Ja,Lee, Dennis,Gaitanopoulos, Dimitri E.,Krawiec, John A.,Parks, Derek J.,Webb, Christine L.,Ziegler, Kelly,Jaye, Michael,Thompson, Scott K.
experimental part, p. 5617 - 5621 (2010/04/30)
The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism. SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.
AMIDE COMPOUNDS AND METHODS OF USING THE SAME
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Page 56-57, (2010/02/07)
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME
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Page/Page column 32; 42, (2008/06/13)
Disclosed is a compound of having the formula (II-A), pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
