61034-15-9

Usage

Derivative of purine

1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-8-(phenylamino)is derived from the purine class of compounds, which are a group of organic compounds consisting of a pyrimidine ring fused to an imidazole ring.

Bronchodilator

Theophylline is used to treat breathing problems by acting as a bronchodilator, which helps to relax and open the airways in the lungs.

Treatment of respiratory conditions

Theophylline is used to treat breathing problems caused by asthma, chronic bronchitis, and emphysema, which are all respiratory conditions that affect the airways and breathing.

Muscle relaxation

The compound works by relaxing the muscles in the airways, which helps to open up the air passages and improve breathing for patients with respiratory conditions.

Stimulant effects

Theophylline has stimulant effects on the heart and central nervous system, which can be beneficial in certain medical conditions.

Treatment of apnea in premature infants

Theophylline is sometimes used to treat apnea (pauses in breathing) in premature infants, as its stimulant effects can help to regulate breathing patterns.

Caution and side effects

It is important to use theophylline with caution, as it can have significant side effects and interact with other medications, which may lead to potential health risks or reduced effectiveness of the treatment.

Upstream product

• 10381-75-6 8-bromotheophylline 
• 62-53-3 aniline 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 77012-46-5 chlorure d'amino-4 (chloromethine N-dimethyl iminium)-5 dimethyl-1,3 uracile 

Downstream Products

• 136265-50-4 1,3-Dimethyl-8-phenylamino-7-thietan-3-yl-3,7-dihydro-purine-2,6-dione 
• 78960-51-7 7-(2-Hydroxy-3-phenoxy-propyl)-1,3-dimethyl-8-phenylamino-3,7-dihydro-purine-2,6-dione 
• 91284-91-2 9-Phenyl-1,3-dimethyl-7-iso-butyl-6-hydroxy-9H-8-oxo-pyrimido[2,1-f]purine-2,4-dione 
• 78960-47-1 7-(2,3-dihydroxy-1-propyl)-8-phenylaminotheophylline 
• 76014-26-1 6-Hydroxy-1,3-dimethyl-8-phenyl-5,6,7,8-tetrahydro-1H-1,3,4b,8,9-pentaaza-fluorene-2,4-dione 
• 91284-89-8 9-Phenyl-1,3-dimethyl-7-n-propyl-6-hydroxy-9H-8-oxo-pyrimido[2,1-f]purine-2,4-dione 
• 91284-90-1 9-Phenyl-1,3-dimethyl-7-n-butyl-6-hydroxy-9H-8-oxo-pyrimido[2,1-f]purine-2,4-dione 
• 78960-53-9 7-(2,3-epoxy-1-propyl)-8-phenylaminotheophylline 
• 80248-89-1 1,3-bis(8-phenylamino-7-theophyllinyl)-2-hydroxypropane 
• 80264-56-8 7-(2-hydroxy-3-chloro-1-propyl)-8-phenylaminotheophylline 
• 80248-92-6 9-phenyl-7-chloro-1,3-dimethyl-6,7,8,9-tetrahydropyrimido<2,1-f>purine-2,4-(1H,3H)dione 
• 80248-93-7 9-phenyl-7-acetoxy-1,3-dimethyl-6,7,8,9-tetrahydropyrimido<2,1-f>purine-2,4-(1H,3H)dione 

Relevant academic research and scientific papers

A new entry to the imidazo[4,5-d]pyrimidine system. The reaction of 1,3-dimethyl-6-aminouracil with N,N-dimethyldichloromethyleniminium chloride (phosgeniminium chloride) and trimethylsilyl azide

1,3-Dimethyl-6-aminouracil 2 was converted into various 8-N-arylaminotheophyllines (2-N-arylamino-4,6-dimethylimidazo[4,5-d]pyrimidine-(4H,6H)-5,7-diones ) 17 through reaction successively, with phosgeniminium chloride (N,N-dimethyldichloromethyleniminium chloride) (1a), trimethylsilyl azide (4) and arylamines. Starting with the synthesis of the N,N-dimethyl-(1,3-dimethyl-4-aminouracil-5 yl)chloromethyleniminiun chloride (amide chloride) 3 this new route to the imidazo[4,5-d]pyrimidine skeleton was shown to proceed via the formation of a very unstable N,N-dimethyl-(1,3-dimethyl-4-aminouracil-5-yl)azidomethyleniminium chloride (amide azide) (8) which would undergo an in situ rearrangement into very likely, a 4-amino-5-(chloroformamidin-1'-yl)uracil and/or related compounds of types 10. Depending on reaction conditions, the latter was proved to be a very good precursor of the 8-dimethylaminotheophylline 11 as well.