61040-72-0

Basic information

• Product Name: 1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL
• Synonyms: 1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL
• CAS NO: 61040-72-0
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.23716
• Mol File: 61040-72-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL(61040-72-0)
• EPA Substance Registry System: 1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL(61040-72-0)

Safety Data

• Hazardous Substances Data: 61040-72-0(Hazardous Substances Data)

Usage

General Description

1-(2,4,6-Trimethoxy-phenyl)-prop-2-yn-1-ol is a chemical compound with the molecular formula C12H16O4. It is a propargyl alcohol derivative that contains a phenyl ring substituted with three methoxy groups at the 2, 4, and 6 positions. 1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds. It has also been studied for its potential pharmacological properties, including anti-inflammatory and antioxidant effects. Additionally, its structural features make it a valuable reagent for the development of new drug candidates and scientific applications.

Upstream product

• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 4301-14-8 acetylenemagnesium bromide 
• 74-86-2 acetylene 

Downstream Products

• 61040-73-1 Trimethyl-[1-(2,4,6-trimethoxy-phenyl)-prop-2-ynyloxy]-silane 
• 846541-40-0 1-(2,4,6-Trimethoxy-phenyl)-buta-2,3-dien-1-ol 
• 1379535-27-9 1-(2,4,6-trimethoxyphenyl)prop-2-yn-1-one 
• 1379535-36-0 (Z)-3-(2-hydroxyphenylamino)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-one 
• 1379535-40-6 (Z)-1-(2,4,6-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenylamino)prop-2-en-1-one 
• 61040-79-7 Methyl-4-(2,4,6-trimethoxyphenyl)-hex-2-inoat 

Relevant articles and documents

2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE

Compounds according to Formula (I) are provided and salts thereof, wherein R1, R2, R33, R4, R5, R6, R13, A, X and Y are as defined herein. Methods for preparing compounds of Form

(Z)-1-Aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: Synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies

Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. A series of (Z)-1-aryl-3-arylamino-2- propen-1-one (10) were synthesized and evaluated for antiproliferative activity in cell-based assay. The most active compound (Z)-1-(2-bromo-3,4,5- trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one (10ae) was tested in 20 tumor cell lines including multidrug resistant phenotype and was found to induce apoptosis in all these cell lines with similar GI50 values. Flow cytometry studies showed that 10ae arrested the cells in G2/M phase of cell cycle. In addition to G2/M block, these compounds caused microtubule stabilization like paclitaxel and induced apoptosis via activation of the caspase family. The observations made in this investigation demonstrate that (Z)-1-Aryl-3-arylamino-2-propen-1-one (10) represents a new class of microtubule-stabilizing agents.