61040-72-0

Usage

Uses

Used in Pharmaceutical Research:
1-(2,4,6-Trimethoxy-phenyl)-prop-2-yn-1-ol is used as a building block for the synthesis of biologically active compounds in pharmaceutical research. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2,4,6-Trimethooxy-phenyl)-prop-2-yn-1-ol is used as a valuable reagent for the development of new chemical entities. Its structural features facilitate the synthesis of complex molecules, contributing to the advancement of chemical research and innovation.
Used in Drug Development:
Due to its pharmacological properties, including anti-inflammatory and antioxidant effects, 1-(2,4,6-Trimethooxy-phenyl)-prop-2-yn-1-ol is used as a starting point for the development of new drug candidates. Its potential applications in various therapeutic areas make it a valuable asset in the pharmaceutical industry.
Used in Scientific Applications:
1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL's unique structure and properties also make it a valuable reagent for various scientific applications, such as the study of molecular interactions, the development of novel analytical methods, and the investigation of biological processes.

Upstream product

• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 74-86-2 acetylene 
• 4301-14-8 acetylenemagnesium bromide 

Downstream Products

• 1379535-40-6 (Z)-1-(2,4,6-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenylamino)prop-2-en-1-one 
• 1379535-36-0 (Z)-3-(2-hydroxyphenylamino)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-one 
• 1379535-27-9 1-(2,4,6-trimethoxyphenyl)prop-2-yn-1-one 
• 846541-40-0 1-(2,4,6-Trimethoxy-phenyl)-buta-2,3-dien-1-ol 
• 61040-73-1 Trimethyl-[1-(2,4,6-trimethoxy-phenyl)-prop-2-ynyloxy]-silane 
• 61040-79-7 Methyl-4-(2,4,6-trimethoxyphenyl)-hex-2-inoat 

Relevant academic research and scientific papers

2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE

Compounds according to Formula (I) are provided and salts thereof, wherein R1, R2, R33, R4, R5, R6, R13, A, X and Y are as defined herein. Methods for preparing compounds of Form

Gold(I)-catalysed tandem cyclization of propargyl acetals and alkynes

To expand the understanding of the chemistry of propargyl acetals, their gold(I) catalysed cycloaddition reactions with alkynes have been investigated. We hereby report a novel tandem reaction that allows the construction of a new type of polysubstituted

(Z)-1-Aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: Synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies

Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. A series of (Z)-1-aryl-3-arylamino-2- propen-1-one (10) were synthesized and evaluated for antiproliferative activity in cell-based assay. The most active compound (Z)-1-(2-bromo-3,4,5- trimethoxyphenyl)-3-(3-hydroxy-4-methoxyphenylamino)prop-2-en-1-one (10ae) was tested in 20 tumor cell lines including multidrug resistant phenotype and was found to induce apoptosis in all these cell lines with similar GI50 values. Flow cytometry studies showed that 10ae arrested the cells in G2/M phase of cell cycle. In addition to G2/M block, these compounds caused microtubule stabilization like paclitaxel and induced apoptosis via activation of the caspase family. The observations made in this investigation demonstrate that (Z)-1-Aryl-3-arylamino-2-propen-1-one (10) represents a new class of microtubule-stabilizing agents.

Syntheses and synthetic applications of stannylated allylic alcohols

Allenyl carbinols undergo regioselective hydrostannation in the presence of MoBl3, a catalyst originally developed for the hydrostannation of alkynes, giving rise to allyl stannanes. These allyl stannanes can easily be converted into useful synthetic building blocks such as allyl iodides or vinyl epoxides.