61042-20-4Relevant articles and documents
Diazaborines oxidize slowly with H2O2 but rapidly with peroxynitrite in aqueous buffer
Domaille, Dylan W.,Golzwarden, Julian V. A.,Haggett, Jack G.,Han, Gun Su,Moser, Angela R.,Vyas, Shubham
supporting information, p. 995 - 999 (2022/02/16)
Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) and peroxynitrite (ONOO?) oxidize arylboronic acids to their corresponding phenols. When used in molecular imaging probes and in ROS-responsive molecules, however, simple arylboronic acids struggle to discriminate between H2O2 and ONOO? because of their fast rate of reaction with both ROS. Here, we show that diazaborines (DABs) react slowly with H2O2 but rapidly with peroxynitrite in an aqueous buffer. In addition to their slow reaction with H2O2, the immediate product of DAB oxidation with H2O2 and ONOO? can yield a kinetically trapped CN Z-isomer that slowly equilibrates with its E-isomer. Taken together, our work shows that diazaborines exhibit enhanced kinetic discrimination between H2O2 and ONOO? compared to arylboronic acids, opening up new opportunities for diazaborine-based tools in chemical biology.
Preparation method O - alkyl substituted hydroxylamine salt
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Paragraph 0098; 0102-0103, (2021/11/14)
The invention relates to a preparation method of N - alkyl substituted hydroxylamine salt, and belongs to fine chemical engineering. Pesticide or bulk pharmaceutical chemicals technical field. The present invention reacts with the N - alkyl of the oxime with an inorganic salt of hydroxylamine to give N - alkyl-substituted hydroxylamine salt and oxime. The invention provides an efficient and environment-friendly method for preparing N - alkyl substituted hydroxylamine salt, and simultaneously, an N - alkyl substituted hydroxylamine salt is prepared, and the oxime can be re-prepared to form N - alkylate of oxime so as to realize the material circulation. No equivalent acid is used in the reaction process. Alkali neutralization, avoided the current method to use a large amount of acid, alkali and produce inorganic salt solid waste shortcoming, environmental protection more. The preparation method is mild in reaction condition, and the defects of high pollution and high energy consumption of the traditional process are overcome. In-flight R1 , R2 What is R is as claimed in the claims and the description.
Screening of ligands for the Ullmann synthesis of electron-rich diaryl ethers
Otto, Nicola,Opatz, Till
supporting information; experimental part, p. 1105 - 1111 (2012/09/07)
In the search for new ligands for the Ullmann diaryl ether synthesis, permitting the coupling of electron-rich aryl bromides at relatively low temperatures, 56 structurally diverse multidentate ligands were screened in a model system that uses copper iodide in acetonitrile with potassium phosphate as the base. The ligands differed largely in their performance, but no privileged structural class could be identified.
