61043-41-2Relevant articles and documents
Vitamin B12Derivatives Suitably Tailored for the Synthesis of Photolabile Conjugates
Jackowska, Agnieszka,Gryko, Dorota
supporting information, p. 4940 - 4944 (2021/05/05)
Vitamin B12conjugates are broadly studied in biological sciences. As light offers spatiotemporal control, we decided to develop a method for the preparation of vitamin B12conjugates that release tethered molecules upon exposure to light. Herein, we report vitamin B12derivatives possessing a photolabile linker suitable for conjugation with amines, azides, and alkynes. The potential applications of such conjugates are broad and include the delivery of drugs, labels, and imaging agents to their place of action and spatiotemporal release.