61043-47-8

Basic information

• Product Name: L-Valinamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-
• Synonyms: 3-Carboxypropionyl-L-alanyl-L-alanyl-L-valine-p-nitroanilide
• CAS NO: 61043-47-8
• Molecular Formula: C₂₁H₂₉N₅O₈
• Molecular Weight: 479.4837
• EINECS: 262-569-3
• Product Categories: Activity;Enzyme Substrates;Fluorogenic
• Mol File: 61043-47-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 847.9°C at 760 mmHg
• Flash Point: 466.6°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 1.45E-30mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: -15°C
• CAS DataBase Reference: L-Valinamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valinamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-(61043-47-8)
• EPA Substance Registry System: L-Valinamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-(61043-47-8)

Safety Data

• Hazardous Substances Data: 61043-47-8(Hazardous Substances Data)

Usage

General Description

L-Valinamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)- is a complex chemical compound with a long name. It is a derivative of valine, an essential amino acid, and contains a carboxy-oxo-propyl group, as well as a nitrophenyl group. L-Valinamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)- may have potential use in pharmaceutical research and drug development, due to its complex structure and potential biological activity. It is likely being investigated for its potential as a therapeutic agent or in biochemical studies related to amino acids and peptides. The precise functions and applications of this compound would require further research and analysis.

InChI:InChI=1/C21H29N5O8/c1-11(2)18(24-14-5-7-15(8-6-14)26(33)34)21(32)25-20(31)13(4)23-19(30)12(3)22-16(27)9-10-17(28)29/h5-8,11-13,18,24H,9-10H2,1-4H3,(H,22,27)(H,23,30)(H,28,29)(H,25,31,32)/t12-,13-,18-/m0/s1

Downstream Products

• 52084-13-6 L-valine para-nitroanilide 
• 141509-27-5 N-succinyl-Ala-Ala 
• 100-01-6 4-nitro-aniline 

Relevant articles and documents

p-Nitroanilides of 3-carboxypropionyl-peptides. Their cleavage by elastase, trypsin, and chymotrypsin.

Fourteen 3-carboxypropionyl-tripeptide-p-nitroanilides of the general formula 3-carboxypropionyl-alanyl-alanyl-Y-p-nitroanilide (Y = glycine, norvaline, S-methylcysteine, valine, norleucine, S-ethylcysteine, methionine, leucine, isoleucine, phenylalanine, tyrosine, S-benzylcysteine, Calpha-phenylglycine, and proline) were synthesized and their cleavage by elastase, trypsin, and chymotrypsin (Km, kcat and kcat/Km) was determined. The significance of amino acid residues in the position of Y was evaluated firstly with respect to their structure (topographically), and secondly with respect to their free energy (thermodynamically). The alanine residue substrate was cleaved best by elastase, the phenylalanine substrate by chymotrypsin. Trypsin cleaved two substrates only, that is those containing a phenylalanine and a tyrosine residue. The optimum length of the elastolytic substrates was studied in a series of N-3-carboxypropionyl-(Ala)n-p-nitroanilides (n = 1, 2, 3, 4, 5), N-3-carboxypropionyl-(Gly)n-p-nitroanilides (n = 1, 2, 3), and in p-nitroanilides of fatty acids with two to seven carbon atoms. Elastase cleaved tri, tetra, and pentapeptides of alanine. p-Nitroanilides of the glycine series, as well as p-nitroanilides of fatty acids were not cleaved. 3-Carboxypropionyl-tetra-alanine-p-nitroanilide was the most suitable substrate so far found for elastase cleavage; it is not cleaved by trypsin nor chymotrypsin. The optimum distance between Y and the terminal anionic carboxyl residue was found to be 1.8 nm in elastolytic substrates.