6106-07-6

Basic information

• Product Name: Sodium levothyroxine pentahydrate
• Synonyms: 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE SODIUM SALT PENTAHYDRATE;3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE PENTAHYDRATE;3,3',5,5'-TETRAIODO-L-THYRONINE SODIUM SALT PENTAHYDRATE;L-THYROXINE SODIUM PENTAHYDRATE;L-THYROXINE SODIUM SALT PENTAHYDRATE;(S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT PENTAHYDRATE;SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE PENTAHYDRATE;SODIUM LEVOTHYROXINE PENTAHYDRATE
• CAS NO: 6106-07-6
• Molecular Formula: C15H20I4NNaO9
• Molecular Weight: 888.93
• EINECS: 200-221-4
• Product Categories: Hormones
• Mol File: 6106-07-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 207-210 (dec.)(lit.)
• Appearance: /powder
• Density: 2.381
• Storage Temp.: 2-8°C
• Solubility: cell culture medium: 0.1 mg/mL
• BRN: 5721845
• CAS DataBase Reference: Sodium levothyroxine pentahydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium levothyroxine pentahydrate(6106-07-6)
• EPA Substance Registry System: Sodium levothyroxine pentahydrate(6106-07-6)

Safety Data

• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 22-24/25-36
• WGK Germany: 3
• RTECS: YP2833760
• F: 3-8-10
• Hazardous Substances Data: 6106-07-6(Hazardous Substances Data)

Usage

Hazard

A reproductive hazard.

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Purification Methods

Crystallise the sodium salt from absolute EtOH and dry it for 8hours at 30o/1mm. [Canepa Acta Cryst 4 283 1951, Beilstein 14 II 378, 14 III 1566, 14 IV 2374.]