6106-21-4

Basic information

• Product Name: Disodium succinate hexahydrate
• Synonyms: DI-SODIUM SUCCINATE HEXAHYDRATE;FEMA 3277;BUTANEDIOIC ACID DISODIUM SALT HEXAHYDRATE;SUCCINIC ACID, DISODIUM SALT, 6-HYDRATE;SUCCINIC ACID DISODIUM SALT HEXAHYDRATE;SUCCINIC ACID, SODIUM SALT;SODIUM SUCCINATE;SODIUM SUCCINATE 6-HYDRATE
• CAS NO: 6106-21-4
• Molecular Formula: C4H16Na2O10
• Molecular Weight: 270.14
• EINECS: 205-778-7
• Product Categories: Building Blocks;Carbonyl Compounds;Carboxylic Acid Salts;Chemical Synthesis;Optimization Reagents;Organic Building Blocks;Protein Structural Analysis;Proteomics;X-Ray Crystallography
• Mol File: 6106-21-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 300 °C
• Boiling Point: 236.1 °C at 760 mmHg
• Flash Point: 110.9 °C
• Appearance: White/Liquid
• Storage Temp.: Store at room temperature.
• Solubility: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility: 349 g/L (35 ºC)
• Sensitive: Hygroscopic
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 14,8679
• BRN: 3921044
• CAS DataBase Reference: Disodium succinate hexahydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Disodium succinate hexahydrate(6106-21-4)
• EPA Substance Registry System: Disodium succinate hexahydrate(6106-21-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• RTECS: WM7751000
• TSCA: Yes
• Hazardous Substances Data: 6106-21-4(Hazardous Substances Data)

Usage

Uses

Used in Food Industry:
Disodium succinate hexahydrate is used as an acidulant and flavoring agent for enhancing the taste and quality of various food products.
Used in Agricultural Industry:
Disodium succinate hexahydrate serves as a protective coating for fruits and vegetables, helping to preserve their freshness and extend their shelf life.
Used in Pharmaceutical Industry:
Disodium succinate hexahydrate is used as an ingredient in topical preparations for the treatment of cataract, aiding in the management and improvement of eye health.
Used in Medical Research:
In conjunction with Melatonin, disodium succinate hexahydrate has been found to reduce liver mitochondrial dysfunction in rats with diabetes mellitus, showcasing its potential in medical research and treatment of related health conditions.

InChI:InChI=1/C4H6O4.Na.6H2O/c5-3(6)1-2-4(7)8;;;;;;;/h1-2H2,(H,5,6)(H,7,8);;6*1H2/q;+1;;;;;;/p-2

Synthetic route

4,4'-bipyridine (553-26-4) + nickel(II) nitrate hexahydrate + water (7732-18-5) + disodium succinate hexahydrate (6106-21-4) → [Ni(succinate)(4,4'-bipyridine)(H2O)2]*H2O

Conditions	Yield
In water; N,N-dimethyl-formamide DMF soln. of bipy added to aq. soln. of Ni compd., mixt. stirred for 10 min, aq. soln. of Na2suc added (1:1:1 molar ratio), mixt. stirred for 30min, heated at 80°C for 3 d; cooled slowly to room temp., septd., washed (H2O), dried in air, elem. anal.;	75%

4,4'-bipyridine (553-26-4) + nickel(II) nitrate hexahydrate + water (7732-18-5) + disodium succinate hexahydrate (6106-21-4) → [Ni(succinate)(4,4'-bipyridine)(H2O)2]*2H2O

Conditions	Yield
In water; N,N-dimethyl-formamide High Pressure; DMF soln. of bipy added to aq. soln. of Ni compd., mixt. stirred for 10 min, aq. soln. of Na2suc added (1:1:1 molar ratio), mixt. stirred for 30min, sealed, heated at 120°C for 3 d; cooled slowly to room temp., septd., washed (H2O), dried in air, elem. anal.;	74%

diaqua-bis(2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol)Zn(II) perchlorate + water (7732-18-5) + disodium succinate hexahydrate (6106-21-4) → diaqua-bis(2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol)Zn(II) succinate monohydrate

Conditions	Yield
In methanol; water mixt. of ((Zn(HFlu)2(H2O)2)(ClO4)2)n (0.4 mmol) and sodium succinate (0.4 mmol) in H2O/MeOH (1:1), stirred for 50 min; filtered, crystd. at 40°C for 7 d; XRD, elem. anal.;	41%

diaqua-bis(2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol)Cd(II) perchlorate + water (7732-18-5) + disodium succinate hexahydrate (6106-21-4) → diaqua-bis(2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol)Cd(II) succinate monohydrate

Conditions	Yield
In methanol; water mixt. of ((Cd(HFlu)2(H2O)2)(ClO4)2)n (0.4 mmol) and sodium succinate (0.4 mmol) in H2O/MeOH (1:1), stirred for 50 min; filtered, crystd. at 40°C for 7 d; XRD, elem. anal.;	38%

[Co(N-(2-picolyl)isoindoline-1-(2-picolyl)imine)Cl2] + water (7732-18-5) + disodium succinate hexahydrate (6106-21-4) → {[Co(N-(2-picolyl)isoindoline-1-(2-picolyl)imine)(succinate)]*2.6H2O}

Conditions	Yield
at 99.84℃; for 16h; Sealed tube;	37%

copper(II) choride dihydrate + disodium succinate hexahydrate (6106-21-4) → copper(II) succinate dihydrate

Conditions	Yield
In water aq. soln. of org. compd. added to stirred aq. soln. of Cu salt; sepd. by centrifugation, washed until no Cl(1-) ion detected;

manganese(II) sulfate + disodium succinate hexahydrate (6106-21-4) + 1,10-phenanthroline hydrate (5144-89-8) → [Mn2(H2O)4(1,10-phenanthroline)2((CH2COO)2)2]*2H2O + [Mn(1,10-phenanthroline)2(H2O)2][Mn(1,10-phenanthroline)((CH2COO)2)](CH2COO)2*7H2O

Conditions	Yield
In methanol; water org. compds. dissolved in MeOH/H2O, soln. of MnSO4 added dropwise by stirring; slow evapd. at room temp. for several weeks;

copper(II) nitrate hydrate + disodium succinate hexahydrate (6106-21-4) → copper succinate dihydrate

Conditions	Yield
With cetyltetraammoniummethyl bromide In 2,2,4-trimethylpentane; water; butan-1-ol cetyltetraammoniummethyl bromide, n-butanol, isooctane and aq. soln. of Cu(NO3)2*nH2O mixed with sodium succinate hexahydrate, stirred overnightat room temp.; sepd., washed with CHCl3 and MeOH 1:1, dried at room temp.;

water (7732-18-5) + disodium succinate hexahydrate (6106-21-4) + cerous nitrate → cerium(III) sussinate pentahydrate

Conditions	Yield
In H2O prepn. by adding slowly, with continuous stirring, soln. of ligand to hot soln. of metal salt (pH 5) until ppt. was obtained; ppt. washed (H2O); filtered; dried on filter; kept in desiccator (anhyd.CaCl2); elem. anal.;

water (7732-18-5) + samarium(III) chloride (10361-82-7) + disodium succinate hexahydrate (6106-21-4) → samarium(III) sussinate pentahydrate

Conditions	Yield
In H2O prepn. by adding slowly, with continuous stirring, soln. of ligand to hot soln. of metal salt (pH 5) until ppt. was obtained; ppt. washed (H2O); filtered; dried on filter; kept in desiccator (anhyd.CaCl2); elem. anal.;

water (7732-18-5) + disodium succinate hexahydrate (6106-21-4) + europium(III) chloride (10025-76-0) → europium(III) sussinate tetrahydrate

Conditions	Yield
In H2O prepn. by adding slowly, with continuous stirring, soln. of ligand to hot soln. of metal salt (pH 5) until ppt. was obtained; ppt. washed (H2O); filtered; dried on filter; kept in desiccator (anhyd.CaCl2); elem. anal.;

water (7732-18-5) + neodymium trichloride (10024-93-8) + disodium succinate hexahydrate (6106-21-4) → neodymium(III) sussinate tetrahydrate

Conditions	Yield
In H2O prepn. by adding slowly, with continuous stirring, soln. of ligand to hot soln. of metal salt (pH 5) until ppt. was obtained; ppt. washed (H2O); filtered; dried on filter; kept in desiccator (anhyd.CaCl2); elem. anal.;

water (7732-18-5) + lanthanum(III) chloride (10099-58-8) + disodium succinate hexahydrate (6106-21-4) → lanthanum(III) sussinate pentahydrate

Conditions	Yield
In H2O prepn. by adding slowly, with continuous stirring, soln. of ligand to hot soln. of metal salt (pH 5) until ppt. was obtained; ppt. washed (H2O); filtered; dried on filter; kept in desiccator (anhyd.CaCl2); elem. anal.;

water (7732-18-5) + praseodymium(III) chloride (10361-79-2) + disodium succinate hexahydrate (6106-21-4) → praseodymium(III) sussinate tetrahydrate

Conditions	Yield
In H2O prepn. by adding slowly, with continuous stirring, soln. of ligand to hot soln. of metal salt (pH 5) until ppt. was obtained; ppt. washed (H2O); filtered; dried on filter; kept in desiccator (anhyd.CaCl2); elem. anal.;

water (7732-18-5) + gadolinium(III) chloride (10138-52-0) + disodium succinate hexahydrate (6106-21-4) → gadolinium(III) sussinate pentahydrate

Conditions	Yield
In H2O prepn. by adding slowly, with continuous stirring, soln. of ligand to hot soln. of metal salt (pH 5) until ppt. was obtained; ppt. washed (H2O); filtered; dried on filter; kept in desiccator (anhyd.CaCl2); elem. anal.;

disodium succinate hexahydrate (6106-21-4) → [Cu(C5H4N)2(H2O)2((CH2COO)2)]*2H2O

Conditions	Yield
Multi-step reaction with 2 steps 1: water 2: ammonia / water; methanol View Scheme

iron(II) chloride tetrahydrate + disodium succinate hexahydrate (6106-21-4) → ferrous succinate

Conditions	Yield
In water at 100℃; for 14h; Glovebox;