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6106-46-3 Usage


Transderm ,Scop Novartis Consumer Health Inc.


(-)Scopolamine Methylnitrate is a competitive antimuscarinic agent.

Manufacturing Process

In a one-liter separatory funnel, 94 g (0.215 mol) of scopolamine hydrobromide trihydrate was dissolved in 250 ml of water, made alkaline by shaking with 40 g (1 mol) of sodium hydroxide in 150 ml of water, and the free base immediately extracted with ether. As scopolamine is somewhat soluble in water, the aqueous layer was saturated with potassium carbonate and again extracted with ether. The combined ether extracts were dried over anhydrous magnesium sulfate and the ether removed by distillation, leaving 65 g (0.214 mol; 100% yield) of nearly colorless oil. Then 100 g (1.05 mol) of cold methyl bromide was added to a chilled, 500-ml pressure flask containing the 65 g of scopolamine, the flask stoppered tightly with a clamp, and allowed to stand at room temperature for 96 hours. The flask was cooled before opening, excess methyl bromide removed by distilling, and the white solid washed thoroughly with dry ether. The yield of crude Nmethylscopolammonium bromide was 80 g (94 %t yield). The salt was recrystallized from 550 ml of alcohol; first crop, 70 g, MP: 212-214°C; second crop, 6 g, melting point 195-200°C. The combined crops were again recrystallized from 500 ml of alcohol; melting point 210-212°C. The third recrystallization from 600 ml of alcohol yielded 64 g, melting point 214- 216°C, a 75 % yield based on scopolamine hydro-bromide trihydrate starting material. N-Methylscopolammonium bromide may be dissolved in water. An equivalent of solution AgNO3 was added, a precipitated AgBr was filtered off. The filtrate was evaporated to dryness to give the desired Nmethylscopolammonium nitrate.

Brand name


World Health Organization (WHO)

Hyoscine methonitrate, a quaternary ammonium anticholinergic agent, was introduced in 1947 for use as a gastrointestinal antispasmodic. The action taken in Sweden relates to the use of this compound in preparations for suppressing the appetite. Preparations may remain available elsewhere.

Check Digit Verification of cas no

The CAS Registry Mumber 6106-46-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,0 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6106-46:
73 % 10 = 3
So 6106-46-3 is a valid CAS Registry Number.

6106-46-3 Well-known Company Product Price

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  • TCI America

  • (S0230)  Scopolamine Methyl Nitrate  >98.0%(HPLC)(T)

  • 6106-46-3

  • 1g

  • 880.00CNY

  • Detail
  • TCI America

  • (S0230)  Scopolamine Methyl Nitrate  >98.0%(HPLC)(T)

  • 6106-46-3

  • 5g

  • 2,560.00CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Scopolamine Methyl Nitrate

1.2 Other means of identification

Product number -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6106-46-3 SDS

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