61070-20-0

Basic information

• Product Name: BOC-HIS(1-ME)-OH
• Synonyms: N-ALPHA-T-BUTOXYCARBONYL-N-IM-1-METHYL-L-HISTIDINE;BOC-HIS(1-ME)-OH;BOC-HIS(N-IM-ME)-OH;BOC-HIS(T-ME)-OH;BOC-HISTIDINE(1-ME)-OH;BOC-N-IM-METHYL-L-HISTIDINE;Boc-His(tau-Me)-OH;N-BOC-N-IM-1-METHYL-L-HISTIDINE
• CAS NO: 61070-20-0
• Molecular Formula: C₁₂H₁₉N₃O₄
• Molecular Weight: 269.3
• Mol File: 61070-20-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 166-168 °C (decomp)
• Boiling Point: 502.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.17±0.10(Predicted)
• CAS DataBase Reference: BOC-HIS(1-ME)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-HIS(1-ME)-OH(61070-20-0)
• EPA Substance Registry System: BOC-HIS(1-ME)-OH(61070-20-0)

Safety Data

• Hazardous Substances Data: 61070-20-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 17791-52-5 N-(tert-butoxycarbonyl)-L-histidine 
• 74-88-4 methyl iodide 

Downstream Products

• 1448429-04-6 (2S,3S)-3-((S)-1-(4-(4-fluorophenyl)thiazol-2-ylamino)-3-(1-methyl-1H-imidazol-4-yl)-1-oxopropan-2-ylcarbamoyl)oxirane-2-carboxylic acid 
• 1448429-48-8 (2S,3S)-ethyl 3-((S)-1-(4-(4-fluorophenyl)thiazol-2-ylamino)-3-(1-methyl-1H-imidazol-4-yl)-1-oxopropan-2-ylcarbamoyl)oxirane-2-carboxylate 
• 1449231-53-1 C₂₁H₂₄FN₅O₃S 
• 876366-44-8 [1-(3,5-dimethyl-phenylcarbamoyl)-2-(1-methyl-1H-imidazol-4-yl)-ethyl]-carbamic asid tert-butyl ester 
• 146879-02-9 N-(tert-butoxycarbonyl)-τ-methyl-L-histidine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 1562430-34-5 C₃₅H₄₄N₆O₅S 
• 1053255-26-7 {2-[(S)-1-{(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-thiophen-2-yl-ethylcarbamoyl}-2-(4-methoxy-phenyl)-ethylcarbamoyl]-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

MITOCHONDRIA-TARGETING PEPTIDES

Disclosed are non-natural peptides useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.

Formamides derived from N-methyl amino acids serve as new chiral organocatalysts in the enantioselective reduction of aromatic ketimines with trichlorosilane

Asymmetric reduction of N-aryl ketimines 1a-k, 43, and 45 with trichlorosilane can be catalyzed by new N-methyl l-amino acid-derived Lewis-basic organocatalysts, such as the valine-derived bisamide 3d (10 mol%), in toluene at room temperature with high enantioselectivity (≤92% ee). The structure-reactivity investigation shows that the product configuration is controlled by the nature of the side chain of the catalyst scaffold (e.g., i-Pr vs Me, as in 3d and 6e), so that catalysts of the same absolute configuration may induce the formation of the opposite enantiomers of the product. Arene-arene interactions between the catalyst and the incoming imine appear to be the prerequisite for asymmetric induction. This metal-free, organocatalytic protocol is competitive with the traditional, metal-catalyzed methodology.