610785-40-5

Basic information

• Product Name: 17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
• Synonyms: 17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
• CAS NO: 610785-40-5
• Molecular Weight: 420.549
• Mol File: 610785-40-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone(610785-40-5)
• EPA Substance Registry System: 17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone(610785-40-5)

Safety Data

• Hazardous Substances Data: 610785-40-5(Hazardous Substances Data)

Upstream product

• 534-22-5 2-methylfuran 
• 95716-71-5 Δ⁹⁽¹¹⁾-canrenone 

Downstream Products

• 107724-20-9 eplerenone 
• 95716-70-4 17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester 

Relevant articles and documents

Preparation method of eplerenone with high efficiency and low pollution

The invention discloses a preparation method of eplerenone with high efficiency and low pollution, and belongs to the technical field of preparation and processing of steroid hormone drugs. The methodcomprises the steps: by taking a compound I, namely delta 9,11-canrenone, as an initial raw material, carrying out 7-furyl addition, furyl ring opening and lactonization cyclization reaction to obtain 5,7-lactone, and carrying out ring opening methylation and 9,11-double bond epoxidation reaction to obtain the eplerenone. According to the method, raw materials and reagents are cheap and easy to obtain, and the method has extremely high market competitiveness in equipment investment and production cost; reagents used in the method are low in environmental pollution, and particularly cyano-containing high-toxicity compounds are not used, so that the method is greener and more environment-friendly; the production process is easy to control, high in yield, low in cost and suitable for industrial production.

Process to prepare eplerenone

The present invention involves intermediates, including a 7α-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.