61097-72-1Relevant articles and documents
Mild Cu-Catalyzed Oxidation of Benzylic Boronic Esters to Ketones
Grayson, James D.,Partridge, Benjamin M.
, p. 4296 - 4301 (2019)
The oxidation of benzylic boronic esters directly to the ketone is reported. This mild Cu-catalyzed method uses an ambient atmosphere of air as the terminal oxidant and is notably chemoselective. Oxidation of the C-B bond occurs selectively, even in the presence of unprotected alcohols. Initial investigation suggests the reaction proceeds through an alkylboron to Cu transmetalation, peroxide formation, and rearrangement to give the carbonyl.