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611-20-1

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Product FOB Price Min.Order Supply Ability Supplier
2-Cyanophenol
Cas No: 611-20-1
No Data 1 Milligram 5 Xiamen Jenny Chemical Technology Co., Ltd. Contact Supplier
2-Hydroxybenzonitrile; Salicylonitrile
Cas No: 611-20-1
No Data 1 Milligram 1 Metric Ton/Day BAYNOE CHEM CO.,LTD Contact Supplier
2-Cyanophenol
Cas No: 611-20-1
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 2-Cyanophenol supplier in China
Cas No: 611-20-1
No Data 1 Kilogram 3000 Metric Ton/Year Simagchem Corporation Contact Supplier
Large Stock 99.0% 2-Cyanophenol 611-20-1 Producer
Cas No: 611-20-1
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
611-20-12-Cyanophenol
Cas No: 611-20-1
No Data 1 Kilogram 20 Metric Ton/Day Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply Salicylonitrile
Cas No: 611-20-1
No Data 1 1 Ality Chemical Corporation Contact Supplier
2-Cyanophenol
Cas No: 611-20-1
No Data 100 Gram 5 Metric Ton/Month Wuhan Kemi-Works Chemical Co., Ltd Contact Supplier
2-Cyanophenol
Cas No: 611-20-1
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
2-Hydroxybenzonitrile
Cas No: 611-20-1
USD $ 5.0-5.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier

611-20-1 Usage

Chemical Properties

white to light yellow crystal powder

Uses

2-Hydroxybenzonitrile is used as starting reagent during the synthesis of mono-alkoxyphenyloxazoline, furanoside.
InChI:InChI=1/C7H5NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H

611-20-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A13606)  2-Hydroxybenzonitrile, 98%    611-20-1 5g 299.0CNY Detail
Alfa Aesar (A13606)  2-Hydroxybenzonitrile, 98%    611-20-1 25g 1056.0CNY Detail
Alfa Aesar (A13606)  2-Hydroxybenzonitrile, 98%    611-20-1 100g 3541.0CNY Detail

611-20-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Hydroxybenzonitrile

1.2 Other means of identification

Product number -
Other names 2-Cyanophenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:611-20-1 SDS

611-20-1Synthetic route

(E)-2-hydroxylbenzaldehyde oxime
21013-96-7

(E)-2-hydroxylbenzaldehyde oxime

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With 1,3,5-trichloro-2,4,6-triazine In N,N-dimethyl-formamide at 20℃; for 4h; Beckmann rearrangement;100%
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 1h; Solvent; Mitsunobu Displacement; Inert atmosphere;97%
With aluminum oxide; methanesulfonyl chloride at 100℃; for 0.0833333h;94%
2-fluorobenzonitrile
394-47-8

2-fluorobenzonitrile

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With 2-(methylsulfonyl)ethyl alcohol; sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;100%
With methyl propargyl alcohol; potassium tert-butylate In dimethyl sulfoxide at 125℃; for 0.0333333h; microwave irradiation;73%
Multi-step reaction with 3 steps
1.1: 94 percent / NaH / dimethylformamide / 3 h / 70 °C
2.1: 7.08 g / ICl; K2CO3 / CH2Cl2 / 1 h / Heating
3.1: iPrMgCl / tetrahydrofuran / 0.52 h / -78 °C
3.2: ZnCl2 / tetrahydrofuran / -78 - 20 °C
3.3: Pd(PPh3)4 / tetrahydrofuran; dimethylformamide / 18 h / 20 °C
View Scheme
2-(tert-butoxy)benzonitrile
218797-78-5

2-(tert-butoxy)benzonitrile

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With sodium iodide; cerium(III) chloride In acetonitrile at 40℃; for 6h;100%
Multi-step reaction with 2 steps
1: potassium tert-butylate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere; Sealed tube
2: potassium tert-butylate; 18-crown-6 ether; water / 1,4-dioxane / 16 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium tert-butylate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere; Sealed tube
2: potassium tert-butylate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere; Sealed tube; Glovebox
3: potassium tert-butylate; 18-crown-6 ether; water / 1,4-dioxane / 16 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium tert-butylate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere; Sealed tube
2: potassium tert-butylate; 18-crown-6 ether / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Sealed tube
3: potassium tert-butylate; 18-crown-6 ether; water / 1,4-dioxane / 16 h / 20 °C
View Scheme
salicylaldehyde-oxime
94-67-7

salicylaldehyde-oxime

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With chlorosulfonic acid In toluene at 90℃; for 0.5h;99%
With oxalyl dichloride; Tropone; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 0.166667h; Schlenk technique; Inert atmosphere;99%
With acetyl chloride; zinc(II) oxide for 0.5h; Heating;95%
2-(prop-2'-enyloxy)benzonitrile
97960-34-4

2-(prop-2'-enyloxy)benzonitrile

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With tetrabutylammonium tetrafluoroborate; tris(2,2'-bipyridine)nickel(II) tetrafluoroborate In N,N-dimethyl-formamide Ambient temperature; electrolysis: Mg rod anode, carbon fibre cathode, const. current 60 mA;99%
2-(prop-2-yn-1-yloxy)benzonitrile
65211-56-5

2-(prop-2-yn-1-yloxy)benzonitrile

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
tris(2,2'-bipyridine)nickel(II) tetrafluoroborate In N,N-dimethyl-formamide Ambient temperature; electrolysis;99%
salicylamide
65-45-2

salicylamide

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With phosgene; L-lysine In 1,2-dichloro-ethane at 80℃; for 4h; Reagent/catalyst; Temperature;98.8%
With phosgene; cyanex-921 In 1,2-dichloro-ethane for 4h; Reagent/catalyst; Solvent; Reflux;98.9%
With thionyl chloride In 5,5-dimethyl-1,3-cyclohexadiene at 105℃; for 7h; Concentration; Temperature; Solvent; Reagent/catalyst;97.8%
2-hydroxy-benzoic acid ethyl ester
118-61-6

2-hydroxy-benzoic acid ethyl ester

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With ammonia; boron phosphate at 400℃; for 0.000277778h;98%
Multi-step reaction with 2 steps
1: alcohol; ammonia / 100 °C
2: phosphorus pentoxide
View Scheme
Multi-step reaction with 2 steps
1: alcohol; ammonia / 100 °C
2: phosphorus pentoxide
View Scheme
Multi-step reaction with 3 steps
1: alcohol; ammonia / 100 °C
2: P2S5
3: bei der Destillation unter vermindertem Druck
View Scheme
2-hydroxy-benzaldehyde O-phenyl-oxime

2-hydroxy-benzaldehyde O-phenyl-oxime

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With zirconium(IV) chloride In nitromethane for 0.0333333h; Heating;97%
salicylonitril; ammonium salt
114536-52-6

salicylonitril; ammonium salt

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With ammonia; N,N-dimethyl-formamide; Xylene; mixture of at 420℃; Product distribution / selectivity;97%
With sulfuric acid; ammonia; water at 60℃; pH=3 - 4; Product distribution / selectivity;96%
With ammonia; Xylene; mixture of at 420℃; Product distribution / selectivity;94%
Stage #1: salicylonitril; ammonium salt With ammonia; water at 15 - 60℃;
Stage #2: In N,N-dimethyl-formamide at 60℃; under 37.5038 - 75.0075 Torr; Product distribution / selectivity;
72%
o-cyanobromobenzene
2042-37-7

o-cyanobromobenzene

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With tris(6,6'-diamino-2,2'-bipyridine); 4,4-diphenyl-1,3,5,7,8-pentamethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene; Br2Ni*3H2O; water; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 24h; Glovebox; Irradiation; Inert atmosphere;97%
With potassium hydroxide; water; polyaniline-supported palladium In 1,4-dioxane at 100℃; for 8h;80%
With oxygen; triethylamine; sodium iodide In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;64%
With formic acid; oxygen; triethylamine; copper(ll) bromide In acetonitrile at 20℃; for 48h; Irradiation;61%
salicylaldehyde
90-02-8

salicylaldehyde

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With iron(III) chloride; hydroxylamine hydrochloride In N,N-dimethyl-formamide for 4h; Reflux;96%
With hydroxylamine hydrochloride In acetonitrile at 70℃; for 15h;96%
With trifluorormethanesulfonic acid; trimethylsilylazide In acetonitrile at 25℃; for 0.00277778h; Schmidt Reaction; Flow reactor;96%
ethanol
64-17-5

ethanol

benzo[d]isoxazol-3-yl(phenyl)methanone
60451-91-4

benzo[d]isoxazol-3-yl(phenyl)methanone

A

salicylonitrile
611-20-1

salicylonitrile

B

benzoic acid ethyl ester
93-89-0

benzoic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide for 16h; Ambient temperature;A 95%
B 90%
5-chloro-2-hydroxybenzonitrile
13589-72-5

5-chloro-2-hydroxybenzonitrile

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With isopropyl alcohol Substitution; Photolysis;95%
salicylaldehyde
90-02-8

salicylaldehyde

potassium ferrocyanide

potassium ferrocyanide

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With Aloe vera mediated silver nanoparticles In water at 50℃; for 1h; Green chemistry;94%
benzoimidazole
51-17-2

benzoimidazole

o-cyanophenylboronic acid-1,3-propylene glycol ester
172732-52-4

o-cyanophenylboronic acid-1,3-propylene glycol ester

A

salicylonitrile
611-20-1

salicylonitrile

B

benzonitrile
100-47-0

benzonitrile

C

2-(1H-benzo[d]imidazol-1-yl)benzonitrile
25699-93-8

2-(1H-benzo[d]imidazol-1-yl)benzonitrile

Conditions
ConditionsYield
With pyridine; water; copper diacetate In N,N-dimethyl-formamide at 30℃; for 24h; Kinetics; Product distribution; Further Variations:; Reaction partners; amount of water;A n/a
B n/a
C 93%
2-Cyanophenylboronic acid
138642-62-3

2-Cyanophenylboronic acid

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; under 760.051 Torr; for 28h; Irradiation; Green chemistry;93%
With 1,10-Phenanthroline; copper(II) sulfate; potassium hydroxide In water at 20℃; for 5h;82%
With C38H34Cl2NP3Pd; oxygen; triethylamine In chloroform at 24.84℃; for 24h;76%
2-Chlorobenzonitrile
873-32-5

2-Chlorobenzonitrile

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With sodium methylate; sodium ethanolate In methanol; ethanol at 170℃; under 760.051 Torr;93%
With oxygen; triethylamine; sodium iodide In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;52%
phosgene
75-44-5

phosgene

hydroxybenzaldoxime
22032-06-0

hydroxybenzaldoxime

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
In toluene92.5%
2-methoxy-benzonitrile
6609-56-9

2-methoxy-benzonitrile

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With 1,3-dimethyl-2-imidazolidinone; lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at 185℃; for 12h; further reagent: NaN(SiMe3)2;91%
With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃; for 18h;10%
With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃; for 18h;10%
2-(2-trimethylsilanylethoxy)benzonitrile

2-(2-trimethylsilanylethoxy)benzonitrile

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
Stage #1: 2-(2-trimethylsilanylethoxy)benzonitrile With cesium fluoride In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere;
Stage #2: With water In N,N-dimethyl-formamide Inert atmosphere;
91%
methyl salicylate
119-36-8

methyl salicylate

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With ammonia; boron phosphate at 400℃; for 0.000277778h;90%
With sodium hexamethyldisilazane In tetrahydrofuran at 185℃; for 24h;85%
Multi-step reaction with 2 steps
1: alcohol; ammonia / 100 °C
2: phosphorus pentoxide
View Scheme
2-methyl-benzyl alcohol
89-95-2

2-methyl-benzyl alcohol

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With aluminum oxide; hydroxylamine hydrochloride; methanesulfonyl chloride at 100℃; for 0.583333h;90%
With Mont KSF; hydroxylamine hydrochloride; silica gel for 0.0666667h; microwave irradiation;89%
With 1,3-dimethyl-2-imidazolidinone; sodium hexamethyldisilazane In tetrahydrofuran at 185℃; for 12h;88%
2-monochlorophenol
95-57-8

2-monochlorophenol

dicyanozinc
557-21-1

dicyanozinc

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With racemic 2-di-tert-butylphosphino-1,1'-binaphthyl; palladium(II) trifluoroacetate; zinc In N,N-dimethyl acetamide at 95℃; for 3h;88.4%
With sulfuric acid; palladium diacetate; zinc; XPhos In 2,4-dichlorophenoxyacetic acid dimethylamine at 120℃; for 2h; Inert atmosphere;98 %Chromat.
salicylic alcohol
90-01-7

salicylic alcohol

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With manganese(IV) oxide; ammonia; magnesium sulfate In tetrahydrofuran; isopropyl alcohol at 20℃; for 18h;87%
potassium hexacyanoferrate(III) trihydrate

potassium hexacyanoferrate(III) trihydrate

2-Iodophenol
533-58-4

2-Iodophenol

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With potassium phosphate In N,N-dimethyl-formamide at 120℃; for 2h;87%
salicylamide
65-45-2

salicylamide

A

salicylonitrile
611-20-1

salicylonitrile

B

phenol
108-95-2

phenol

Conditions
ConditionsYield
tungsten(VI) oxide at 145 - 400℃; under 0.025 Torr; for 1.23333h; Pyrolysis;A 85%
B 8%
With H3PO4 immobilized on aluminium oxide at 480℃;A 50.78 %Chromat.
B 24.12 %Chromat.
methyl thiocyanate
556-64-9

methyl thiocyanate

phenol
108-95-2

phenol

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; boron trichloride; aluminium chloride In 1,2-dichloro-ethane84%
With hydrogenchloride; sodium hydroxide; boron tribromide; aluminium chloride In 1,2-dichloro-ethane79%
With boron trichloride; sodium carbonate Product distribution; various phenols;
With sodium hydroxide; aluminium trichloride; boron trichloride 1.) dichloroethane, 80 deg C, 3 h, 2.) 80 deg C, 30 min; Yield given. Multistep reaction;
2-methoxybenzoic acid methyl ester
606-45-1

2-methoxybenzoic acid methyl ester

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran at 185℃; for 24h;83%
C30H22N2O

C30H22N2O

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
at 40℃; under 0.5 Torr; for 3h;82%
salicylonitrile
611-20-1

salicylonitrile

α-bromoacetophenone
70-11-1

α-bromoacetophenone

(3-amino-benzofuran-2-yl)-phenyl-methanone
49615-93-2

(3-amino-benzofuran-2-yl)-phenyl-methanone

Conditions
ConditionsYield
With potassium carbonate In acetone at 60℃; for 18h; Inert atmosphere;100%
With potassium carbonate In acetone at 60℃; for 18h;100%
With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 1h; Inert atmosphere;96%
salicylonitrile
611-20-1

salicylonitrile

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

methyl 2-(2-cyanophenoxy)ethanoate
34844-79-6

methyl 2-(2-cyanophenoxy)ethanoate

Conditions
ConditionsYield
With potassium carbonate In acetone at 25℃; for 24h; Alkylation;100%
With potassium carbonate In acetone for 7h; Reflux;94%
With potassium carbonate In acetone at 20℃;61.5%
salicylonitrile
611-20-1

salicylonitrile

(R)-2-methyloctan-1-ol
120925-50-0

(R)-2-methyloctan-1-ol

(R)-(-)-2-(1-methylheptyloxy)benzonitrile

(R)-(-)-2-(1-methylheptyloxy)benzonitrile

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate100%
salicylonitrile
611-20-1

salicylonitrile

bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

tert-butyl 2-(2-cyanophenoxy)acetate
609804-44-6

tert-butyl 2-(2-cyanophenoxy)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone at 60℃; for 16h;100%
With potassium carbonate In acetone for 2h; Heating / reflux;
With potassium carbonate In acetone for 2h; Heating / reflux;
salicylonitrile
611-20-1

salicylonitrile

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

2-(piperidin-4-yloxy)-benzonitrile hydrochloride

2-(piperidin-4-yloxy)-benzonitrile hydrochloride

Conditions
ConditionsYield
Stage #1: salicylonitrile; t-butyl 4-hydroxy piperidine-1-carboxylate With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h;
Stage #2: With hydrogenchloride; water In 1,4-dioxane at 20℃; for 18h;
100%
(E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate
131860-97-4

(E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate

salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
With potassium carbonate; quinuclidine hydrochloride In 4-methyl-2-pentanone at 60 - 80℃; for 0.5h; Product distribution / selectivity;100%
With potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 48 - 65℃; for 1h; Product distribution / selectivity;98.3%
Stage #1: (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate; salicylonitrile In N,N-dimethyl-formamide at 60℃; for 0.0833333h;
Stage #2: 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 60℃; for 0.0833333h;
Stage #3: With potassium carbonate In N,N-dimethyl-formamide at 60 - 89℃; for 0.166667h; Product distribution / selectivity;
97.1%
salicylonitrile
611-20-1

salicylonitrile

potassium carbonate
584-08-7

potassium carbonate

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

A

4-(3-bromoanilino)benzofurano[3,2-d]pyrimidine

4-(3-bromoanilino)benzofurano[3,2-d]pyrimidine

B

methyl 2-(2-cyanophenoxy)ethanoate
34844-79-6

methyl 2-(2-cyanophenoxy)ethanoate

Conditions
ConditionsYield
In acetoneA 100%
B n/a
salicylonitrile
611-20-1

salicylonitrile

propargyl bromide
106-96-7

propargyl bromide

2-(prop-2-yn-1-yloxy)benzonitrile
65211-56-5

2-(prop-2-yn-1-yloxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran100%
With potassium carbonate; N,N-dimethyl-formamide In toluene at 50℃; for 16h; Inert atmosphere;94%
With potassium carbonate In N,N-dimethyl-formamide93%
salicylonitrile
611-20-1

salicylonitrile

dimethylamino sulfonyl chloride
13360-57-1

dimethylamino sulfonyl chloride

C9H10N2O3S
1263387-24-1

C9H10N2O3S

Conditions
ConditionsYield
Stage #1: salicylonitrile With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0℃; for 0.166667h;
Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 11h;
100%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

salicylonitrile
611-20-1

salicylonitrile

2-(4-bromobutoxy)benzonitrile

2-(4-bromobutoxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone Reflux;100%
salicylonitrile
611-20-1

salicylonitrile

p-Tolylisocyanate
622-58-2

p-Tolylisocyanate

2-<(4-methylphenyl)aminocarbonyloxy>benzonitrile
88220-35-3

2-<(4-methylphenyl)aminocarbonyloxy>benzonitrile

Conditions
ConditionsYield
With triethylamine In diethyl ether99%
salicylonitrile
611-20-1

salicylonitrile

l-cysteine hydrochloride
52-89-1

l-cysteine hydrochloride

(R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
115921-06-7

(R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol; aq. phosphate buffer for 72h; pH=6; Reflux;99%
Stage #1: salicylonitrile; l-cysteine hydrochloride With sodium hydrogencarbonate In ethanol for 0.5h; Heating;
Stage #2: With piperidine In ethanol for 12h; pH=9; Heating;
Stage #3: With hydrogenchloride In ethanol pH=1.5;
67%
salicylonitrile
611-20-1

salicylonitrile

Methyl 2-bromopropionate
5445-17-0

Methyl 2-bromopropionate

2-[1-(methoxycarbonyl)ethoxy]benzonitrile
182964-51-8

2-[1-(methoxycarbonyl)ethoxy]benzonitrile

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide99%
salicylonitrile
611-20-1

salicylonitrile

4,5-dichloro-2-(tetrahydro-2H-pyran-2-yl)-3(2H)-pyridazinone
173206-13-8

4,5-dichloro-2-(tetrahydro-2H-pyran-2-yl)-3(2H)-pyridazinone

2-[5-chloro-6-oxo-1-(tetrahydro-pyran-2-yl)-1,6-dihydro-pyridazin-4-yloxy]-benzonitrile
1191454-37-1

2-[5-chloro-6-oxo-1-(tetrahydro-pyran-2-yl)-1,6-dihydro-pyridazin-4-yloxy]-benzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 2h; Reflux;99%
salicylonitrile
611-20-1

salicylonitrile

n-pentylmagnesium bromide
693-25-4

n-pentylmagnesium bromide

1-(2-hydroxyphenyl)hexan-1-one
3226-15-1

1-(2-hydroxyphenyl)hexan-1-one

Conditions
ConditionsYield
In tetrahydrofuran at 70℃; Inert atmosphere;99%
Stage #1: salicylonitrile; n-pentylmagnesium bromide In tetrahydrofuran Inert atmosphere; Heating;
Stage #2: With hydrogenchloride; water In tetrahydrofuran Cooling with ice;
salicylonitrile
611-20-1

salicylonitrile

<2H9>trimethylsulphoxonium iodide
23726-00-3

<2H9>trimethylsulphoxonium iodide

2-(methoxy-d3)benzonitrile

2-(methoxy-d3)benzonitrile

Conditions
ConditionsYield
With potassium carbonate at 65℃; for 18h; Sealed tube;99%
salicylonitrile
611-20-1

salicylonitrile

Chloroacetamide
79-07-2

Chloroacetamide

2-(2-cyanophenoxy)acetamide
54802-12-9

2-(2-cyanophenoxy)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃;98.5%
Stage #1: salicylonitrile With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1h;
Stage #2: Chloroacetamide In N,N-dimethyl-formamide at 80℃; for 3h;
With potassium carbonate In N,N-dimethyl-formamide at 80℃;
salicylonitrile
611-20-1

salicylonitrile

2-(1H-tetrazol-5-yl)phenol
51449-77-5

2-(1H-tetrazol-5-yl)phenol

Conditions
ConditionsYield
With hydrogenchloride; sodium azide; water; triethylamine hydrochloride In toluene at 95 - 99℃; for 6h;98%
98%
With sodium azide at 120℃; for 0.333333h;98%
salicylonitrile
611-20-1

salicylonitrile

benzyl bromide
100-39-0

benzyl bromide

2-(benzyloxy)benzonitrile
74511-44-7

2-(benzyloxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 3h;98%
With potassium carbonate In acetone for 2h; Heating;88.6%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;87%
salicylonitrile
611-20-1

salicylonitrile

8-Bromo-1-octene
2695-48-9

8-Bromo-1-octene

2-(oct-7'-enyloxy)benzonitrile

2-(oct-7'-enyloxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate for 6h; Heating;98%
salicylonitrile
611-20-1

salicylonitrile

trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

2-<(trifluoromethanesulfonyl)oxy>benzonitrile
138313-23-2

2-<(trifluoromethanesulfonyl)oxy>benzonitrile

Conditions
ConditionsYield
With pyridine 1.) 0 deg C, 5 min, 2.) r.t., 25 h;98%
With pyridine In dichloromethane at 0 - 25℃; Inert atmosphere;97%
With pyridine In dichloromethane at 20℃; for 0.5h;95%
salicylonitrile
611-20-1

salicylonitrile

Conditions
ConditionsYield
Stage #1: (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 0.0833333h;
Stage #2: salicylonitrile In N,N-dimethyl-formamide at 60℃; for 5h;
Stage #3: 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 60 - 89℃; for 0.166667h; Product distribution / selectivity;
98%
Stage #1: (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate With potassium carbonate In Isopropyl acetate at 40℃; for 0.166667h;
Stage #2: salicylonitrile In Isopropyl acetate for 0.166667h;
Stage #3: 1,4-diaza-bicyclo[2.2.2]octane In Isopropyl acetate at 40 - 45℃; for 0.5h; Product distribution / selectivity;
97.5%
Stage #1: (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate With potassium carbonate In Isopropyl acetate at 40℃; for 0.166667h;
Stage #2: 1,4-diaza-bicyclo[2.2.2]octane In Isopropyl acetate for 0.166667h;
Stage #3: salicylonitrile In Isopropyl acetate at 40 - 45℃; for 0.333333 - 0.5h; Product distribution / selectivity;
94.5%
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