6110-63-0Relevant academic research and scientific papers
Synthesis and crystal structure of chalcones as well as on cytotoxicity and antibacterial properties
Wu, Jianzhang,Wang, Cong,Cai, Yuepiao,Peng, Jing,Liang, Donglou,Zhao, Yunjie,Yang, Shulin,Li, Xiaokun,Wu, Xiaoping,Liang, Guang
experimental part, p. 444 - 452 (2012/08/28)
A series of chalcones derivatives were synthesized and evaluated for cytotoxic and antibacterial activities in vitro. These modifications changed their bioactivity profile and indicated a combination of SAR analysis toward the substituents in rings A and
Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents
Wu, Jianzhang,Li, Jianling,Cai, Yuepiao,Pan, Yong,Ye, Faqing,Zhang, Yali,Zhao, Yunjie,Yang, Shulin,Li, Xiaokun,Liang, Guang
experimental part, p. 8110 - 8123 (2012/01/07)
Major anti-inflammatory agents, steroids and cyclooxygenase, were proved to have serious side effects. Here, a series of chalcone derivatives were synthesized and screened for anti-inflammatory activities. QSAR study revealed that the presence of electron-withdrawing groups in B-ring and electron-donating groups in A-ring of chalcones was important for inhibition of LPS-induced IL-6 expression. Further, compounds 22, 23, 26, 40, and 47 inhibited TNF-α and IL-6 release in a dose-dependent manner and decreased LPS-induced TNF-α, IL-1β, IL-6, IL-12, and COX-2 mRNA production. Mechanistically, compounds 23 and 26 interfered with JNK/NF-κB signaling and dose-dependently prevented ERK and p38 activation. In addition, 23 and 26 exhibited a significant protection against LPS-induced death and were able to block high glucose-activated cytokine profiles in macrophages. Together, these data show a series of anti-inflammatory chalcones with potential therapeutic effects in inflammatory diseases.
Fluorescent α,β-unsaturated carbonyl compounds and 2-methylpyridines. Their application to a quantitative analysis of carnitine
Nakaya, Ken-Ichi,Funabiki, Kazumasa,Shibata, Katsuyoshi,Muramatsu, Hiroshige,Matsui, Masaki
, p. 2961 - 2966 (2007/10/03)
α,β-Unsaturated carbonyl compounds and 2-methylpyridines containing a 4-(dialkylamino)phenyl substituent can be used as fluorescent labeling reagents for the quantitative analysis of carnitine. 6-(4-Aminophenyl)-3-cyano-4-[4-(diethylamino)phenyl]-2-methyl
