611219-85-3Relevant academic research and scientific papers
Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists
Madsen-Duggan, Christina B.,Debenham, John S.,Walsh, Thomas F.,Toupence, Richard B.,Huang, Song X.,Wang, Junying,Tong, Xinchun,Lao, Julie,Fong, Tung M.,Schaeffer, Marie-Therese,Xiao, Jing Chen,Huang, Cathy R.-R.C.,Shen, Chun-Pyn,Stribling, D. Sloan,Shearman, Lauren P.,Strack, Alison M.,MacIntyre, D. Euan,Van der Ploeg, Lex H.T.,Goulet, Mark T.
, p. 2031 - 2035 (2008/02/02)
Optimization of the biological activity for 5,6-diarylpyridines as CB1 receptor inverse agonists is described. Food intake and pharmacokinetic evaluation of 3f and 15c indicate that these compounds are effective orally active modulators of CB1.
