611229-04-0Relevant articles and documents
Discovery of quinolines as selective glucocorticoid receptor agonists
Jaroch, Stefan,Berger, Markus,Huwe, Christoph,Krolikiewicz, Konrad,Rehwinkel, Hartmut,Sch?cke, Heike,Schmees, Norbert,Skuballa, Werner
, p. 5835 - 5838 (2010)
The dissociated glucocorticoid receptor (GR) agonist ZK 216348 is rendered GR-selective over other nuclear hormone receptors through replacing the methylbenzoxazine with a quinoline moiety. Compounds were shown to be efficacious in cell assays with respec