61124-55-8Relevant academic research and scientific papers
Preparation of vincinal hetero 1,2-dihalo-olefins by using aqueous hydrohalic acid
Lei, Ya-Ru,Liang, Jia-Ying,Wang, Yu-Jiang,Chen, Zili
supporting information, (2021/04/02)
An efficient simple method was developed to prepare hetero E-1,2-dihaloolefins from mono- or disubstituted alkynes, in which, NXS (X = Br, I) was utilized as the electrophilic reagents and aqueous hydrohalic acid as the nucleophile. Moreover, Z-type dihalogenation olefins could be obtained from the terminal silylacetylene.
Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents
Pfeifer, Lukas,Gouverneur, Véronique
supporting information, p. 1576 - 1579 (2018/03/23)
A novel protocol for the regio- and stereoselective iodofluorination of internal and terminal alkynes using 1,3-diiodo-5,5,-dimethylhydantoin and HF-based reagents is disclosed. This approach is used to prepare a fluorinated tamoxifen derivative in two steps from commercially available starting materials. A facile method enabling controlled regioselective double iodofluorination of terminal alkynes is also presented.
Stereoselective synthesis of iodofluoroalkenes by iodofluorination of alkynes using IF5-pyridine-HF
Ukigai, Hitoshi,Hara, Shoji
supporting information, p. 1379 - 1381 (2018/03/29)
The iodofluorination of alkynes was carried out using IF5-pyridine-HF and hydroquinone. The iodofluorination of an internal alkyne and a terminal alkyne proceeded stereoselectively to give the corresponding iodofluoroalkenes. An unsymmetrically
Iodofluorination of alkenes and alkynes promoted by iodine and 4-iodotoluene difluoride
Conte, Pellegrino,Panunzi, Barbara,Tingoli, Marco
, p. 273 - 276 (2007/10/03)
It was found that a mixture of molecular iodine and 4-iodotoluene difluoride are useful to generate in situ the couple 'IF' that was able to add in a Markovnikov fashion and with prevalent anti-stereoselectivity to various alkenes and alkynes.
