61124-58-1Relevant academic research and scientific papers
Copper-Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines
Lan, Chunling,Tian, Zhuang,Liang, Xuchun,Gao, Mingchun,Liu, Wenting,An, Yu,Fu, Wencheng,Jiao, Guanming,Xiao, Junjie,Xu, Bin
, p. 3735 - 3740 (2017)
A novel method was developed for the construction of biologically active poly-substituted cinnolines from easily accessible hydrazones in good to excellent yields. A simple copper catalyst could efficiently promote C?N bond formation through selective C?H functionalization and dehydrogenative amination. Furthermore, the inert C?Heteroatom (O/F/N) bonds are susceptible to cleavage in high selectivity in the newly developed aerobic annulation, in preference to the alternative C?H bond, which is left intact. (Figure presented.).
