61128-73-2

Basic information

• Product Name: TETRAHYDRO-PYRAN-4-ONE OXIME
• Synonyms: TETRAHYDRO-PYRAN-4-ONE OXIME;N-(oxan-4-ylidene)hydroxylaMine;Dihydro-2H-pyran-4(3H)-one oxiMe;4H-Pyran-4-one, tetrahydro-, oxime
• CAS NO: 61128-73-2
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13
• Mol File: 61128-73-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TETRAHYDRO-PYRAN-4-ONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-PYRAN-4-ONE OXIME(61128-73-2)
• EPA Substance Registry System: TETRAHYDRO-PYRAN-4-ONE OXIME(61128-73-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 61128-73-2(Hazardous Substances Data)

Usage

General Description

Tetrahydro-pyran-4-one oxime, also known as THP-4-one oxime, is a chemical compound with the molecular formula C5H9NO2. It is a white to off-white solid that is commonly used as a building block in organic synthesis. TETRAHYDRO-PYRAN-4-ONE OXIME is often employed as a reagent in the preparation of various heterocyclic compounds and has applications in the production of pharmaceuticals and agrochemicals. Tetrahydro-pyran-4-one oxime is also known for its ability to act as a chelating agent and to form stable complexes with various metal ions. It is important both as a standalone compound and as a precursor to other important chemical products.

Upstream product

• 1194657-31-2 4-nitrosotetrahydro-2H-pyran-4-yl 2,2,2-trichloroacetate 
• 1194657-35-6 4-nitrosotetrahydro-2H-pyran-4-yl pivalate 
• 1194657-13-0 4-nitrosotetrahydro-2H-pyran-4-yl acetate 

Downstream Products

• 10341-26-1 tetrahydro-(2H)-1,4-oxazepin-5-one 
• 61108-59-6 dihydro-2H-pyran-4(3H)-one O-tosyl oxime 
• 1428794-30-2 2-(tert-butoxy)-2-(5-(4-fluorobenzyl)-7-methyl-6-oxo-9-(p-tolyl)-1,3,4,5,6,7-hexahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridin-8-yl)acetic acid 
• 1428795-22-5 methyl 2-(5-(4-fluorobenzyl)-7-methyl-6-oxo-9-(p-tolyl)-1,3,4,5,6,7-hexahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridin-8-yl)-2-hydroxyacetate 
• 1428795-21-4 2-(5-(4-fluorobenzyl)-7-methyl-6-oxo-9-(p-tolyl)-1,3,4,5,6,7-hexahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridin-8-yl)-2-((tetrahydro-2H-pyran-2-yl)oxy)acetonitrile 
• 1428795-20-3 5-(4-fluorobenzyl)-7-methyl-6-oxo-9-(p-tolyl)-1,3,4,5,6,7-hexahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridine-8-carbaldehyde 
• 1428795-19-0 5-(4-fluorobenzyl)-7-methyl-6-oxo-9-(p-tolyl)-1,3,4,5,6,7-hexahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridine-8-carbonyl chloride 
• 1428795-18-9 5-(4-fluorobenzyl)-7-methyl-6-oxo-9-(p-tolyl)-1,3,4,5,6,7-hexahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridine-8-carboxylic acid 
• 1428795-17-8 5-(4-fluorobenzyl)-8-(hydroxymethyl)-7-methyl-9-(p-tolyl)-3,4,5,7-tetrahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridin-6(1H)-one 
• 1428795-16-7 methyl 5-(4-fluorobenzyl)-7-methyl-6-oxo-9-(p-tolyl)-1,3,4,5,6,7-hexahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridine-8-carboxylate 
• 1428795-15-6 methyl 5-(4-fluorobenzyl)-9-hydroxy-7-methyl-6-oxo-1,3,4,5,6,7-hexahydropyrano[3',4':4,5]pyrrolo[2,3-c]pyridine-8-carboxylate 
• 1428795-14-5 1-(4-fluorobenzyl)-3-(methoxycarbonyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2-carboxylic acid 
• 1428795-13-4 methyl 1-(4-fluorobenzyl)-2-((2-methoxy-2-oxoethyl)(methyl)carbamoyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-3-carboxylate 
• 1428795-12-3 1-(4-fluorobenzyl)-1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2,3-dicarboxylic acid 

Relevant articles and documents

New acyloxy nitroso compounds with improved water solubility and nitroxyl (HNO) release kinetics and inhibitors of platelet aggregation

New acyloxy nitroso compounds, 4-nitrosotetrahydro-2H-pyran-4-yl 2,2,2-trichloroacetate and 4-nitrosotetrahydro-2H-pyran-4-yl 2,2-dichloropropanoate were prepared. These compounds release HNO under neutral conditions with half-lives between 50 and 120 min, identifying these HNO donors as kinetically intermediate to the much slower acetate derivative and the faster trifluoroacetic acid derivative. These compounds or HNO-derived from these compounds react with thiols, including glutathione, thiol-containing enzymes and heme-containing proteins in a similar fashion to other acyloxy nitroso compounds. HNO released from these acyloxy nitroso compounds inhibits activated platelet aggregation. These acyloxy nitroso compounds augment the range of release for this group of HNO donors and should be valuable tools in the further study of HNO biology.