61131-60-0Relevant articles and documents
Crystal form of L-lysinate of benzopiperidine derivative and preparation method thereof
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Paragraph 0076-0079, (2020/07/15)
The invention provides a crystal form of a L-lysinate of a benzopiperidine derivative and a preparation method of the crystal form. Specifically, the invention provides a crystal form II of L-lysinateof (E)-3-(4-((1R, 3R)-2-(4-cyclopropyl phenyl)-6-(1-ethyl-1H-pyrazol-4-yl)-3-methyl-1, 2, 3, 4-tetrahydroisoquinoline-1-yl) phenyl) acrylate and a preparation method of the crystal form II. The crystal form II of the compound shown in the formula (I) has good stability and can be better applied to clinical treatment.
TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
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Page/Page column 99, (2017/11/06)
Described herein are tetrahydroisoquinoline compounds with estrogen receptor modulation activity or function having the Formula I structure: I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.