61137-63-1

Basic information

• Product Name: 1-(2-chloroethyl)-3-[(1R,3R)-3-methylcyclohexyl]-1-nitrosourea
• CAS NO: 61137-63-1
• Molecular Formula: C₁₀H₁₈ClN₃O₂
• Molecular Weight: 247.7218
• Mol File: 61137-63-1.mol
• Article Data: 0

Chemical Properties

• Density: 1.31g/cm³
• Refractive Index: 1.575
• CAS DataBase Reference: 1-(2-chloroethyl)-3-[(1R,3R)-3-methylcyclohexyl]-1-nitrosourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-[(1R,3R)-3-methylcyclohexyl]-1-nitrosourea(61137-63-1)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-[(1R,3R)-3-methylcyclohexyl]-1-nitrosourea(61137-63-1)

Safety Data

• Hazardous Substances Data: 61137-63-1(Hazardous Substances Data)

Usage

Description

1-(2-chloroethyl)-3-[(1R,3R)-3-methylcyclohexyl]-1-nitrosourea, commonly known as lomustine, is a chemotherapy drug that functions as an alkylating agent. It is characterized by its ability to disrupt the DNA of cancer cells, resulting in their destruction. Lomustine is typically administered orally and is effective in inhibiting the growth and proliferation of cancer cells.

Uses

Used in Oncology:
Lomustine is used as a chemotherapeutic agent for the treatment of various types of cancer, including brain tumors and Hodgkin's lymphoma. It is particularly effective due to its alkylating properties, which interfere with the DNA of cancer cells, leading to their destruction and preventing further growth and proliferation.
Used in Drug Development:
Lomustine serves as a model for the development of new chemotherapy medications. Its mechanism of action as an alkylating agent provides insights into the design of other drugs that can target and destroy cancer cells by disrupting their DNA.
Used in Cancer Research:
In the field of cancer research, lomustine is utilized to study the effects of alkylating agents on different types of cancer cells. This research helps in understanding the molecular mechanisms of cancer cell death and the potential for developing more effective and targeted cancer therapies.
Used in Pharmaceutical Industry:
Lomustine is an important component in the pharmaceutical industry for the production of cancer treatment medications. Its proven efficacy in treating various types of cancer makes it a valuable asset in the development of new cancer therapies and combination treatments.