6115-02-2Relevant academic research and scientific papers
A simple one-pot synthesis of functionalized ketimines from ketones and amine hydrochloride salts
Selva,Tundo,Marques
, p. 369 - 378 (1995)
Functionalized ketimines of the general formula RR'C (= NCH2Y) [R and R' = Ph, alkyl; Y = CN (1), CH2CI (2), COOMe (3)] have been prepared by the condensation of ketones with the corresponding primary amine hydrochloride salts [NH2CH2CN·HCl (4), NH2CH2CH2Cl·HCl (5) and NH2CH2COOMe·HCl (6), respectively]. The reported reaction proceeds mildly in a single step without the need of a previous isolation of the free amine from its salt. N,N-Dimethylformamide (DMF) is used as the solvent and TiCl4 as the drying agent.
