61153-49-9

Basic information

• Product Name: 2-Propanone, 1,1-difluoro-3-phenyl-
• Synonyms: 2-Propanone, 1,1-difluoro-3-phenyl-;1,1-difluoro-3-phenylpropan-2-one
• CAS NO: 61153-49-9
• Molecular Formula: C₉H₈F₂O
• Molecular Weight: 170.16
• Mol File: 61153-49-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propanone, 1,1-difluoro-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanone, 1,1-difluoro-3-phenyl-(61153-49-9)
• EPA Substance Registry System: 2-Propanone, 1,1-difluoro-3-phenyl-(61153-49-9)

Safety Data

• Hazardous Substances Data: 61153-49-9(Hazardous Substances Data)

Upstream product

• 4250-02-6 1-diazo-3-phenyl-2-propanone 
• 454-31-9 ethyl difluoroacetate 
• 1589-82-8 phenylmagnesium bromide 
• 103-82-2 phenylacetic acid 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 103-80-0 phenylacetyl chloride 
• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 

Downstream Products

• 123986-76-5 (R)-1,1-Difluoro-3-phenyl-propan-2-ol 
• 123986-76-5 (S)-1,1-Difluoro-3-phenyl-propan-2-ol 
• 123986-76-5 1,1-Difluoro-3-phenyl-propan-2-ol 

Relevant articles and documents

A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones

Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre

Difluoromethylation of carboxylic acids via the addition of difluorinated phosphorus ylide to acyl chlorides

A one-step protocol for the difluoromethylation of carboxylic acids is described. The reaction involves the interaction of intermediate acyl chlorides with in situ generated difluorinated phosphorus ylide Ph3P=CF2. Aromatic acids can be selectively transformed within one step either to bis-difluoromethylated alcohols or to difluorinated ketones depending on the particular reaction conditions. For bulky α-branched carboxylic acids, only ketones are produced.

A convenient preparative method for α-trifluoromethyl amines

α-Trifluoromethyl amines (IV) were prepared in three steps: preparation of α-trifluoromethyl ketones (I), their conversion to benzyloximes (II), and reduction of the oximes (II) with lithium aluminium hydride and sodium methoxide. For example, α-trifluoromethyltridecylamine was obtained from the reduction of trifluoromethyl dodecyl ketone benzyl oxime. Elsevier Science S.A.