61153-49-9Relevant articles and documents
A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones
Bi, Xihe,Sivaguru, Paramasivam,Song, Qingmin,Wang, Zikun,Zanoni, Giuseppe,Zhang, Xiaolong,Zhang, Xinyu
supporting information, (2021/12/23)
Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre
Difluoromethylation of carboxylic acids via the addition of difluorinated phosphorus ylide to acyl chlorides
Trifonov, Alexey L.,Levin, Vitalij V.,Struchkova, Marina I.,Dilman, Alexander D.
, p. 5304 - 5307 (2017/11/06)
A one-step protocol for the difluoromethylation of carboxylic acids is described. The reaction involves the interaction of intermediate acyl chlorides with in situ generated difluorinated phosphorus ylide Ph3P=CF2. Aromatic acids can be selectively transformed within one step either to bis-difluoromethylated alcohols or to difluorinated ketones depending on the particular reaction conditions. For bulky α-branched carboxylic acids, only ketones are produced.
A convenient preparative method for α-trifluoromethyl amines
Watanabe, Shoji,Fujita, Tsutomu,Sakamoto, Masami,Hamano, Hiroyuki,Kitazume, Tomoya,Yamazaki, Takashi
, p. 15 - 19 (2007/10/03)
α-Trifluoromethyl amines (IV) were prepared in three steps: preparation of α-trifluoromethyl ketones (I), their conversion to benzyloximes (II), and reduction of the oximes (II) with lithium aluminium hydride and sodium methoxide. For example, α-trifluoromethyltridecylamine was obtained from the reduction of trifluoromethyl dodecyl ketone benzyl oxime. Elsevier Science S.A.