61158-19-8

Basic information

• Product Name: (2-Hydroxy-phenyl)-phenylamino-acetonitrile
• Synonyms: (2-Hydroxy-phenyl)-phenylamino-acetonitrile
• CAS NO: 61158-19-8
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.26
• Mol File: 61158-19-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 119 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 424.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 8.88±0.35(Predicted)
• CAS DataBase Reference: (2-Hydroxy-phenyl)-phenylamino-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Hydroxy-phenyl)-phenylamino-acetonitrile(61158-19-8)
• EPA Substance Registry System: (2-Hydroxy-phenyl)-phenylamino-acetonitrile(61158-19-8)

Safety Data

• Hazardous Substances Data: 61158-19-8(Hazardous Substances Data)

Usage

General Description

(2-Hydroxy-phenyl)-phenylamino-acetonitrile is a chemical compound that belongs to the group of phenylaminoacetonitriles. It is a pale yellow to brown crystalline solid that is commonly used in organic synthesis and as a building block for various pharmaceuticals and agrochemicals. (2-Hydroxy-phenyl)-phenylamino-acetonitrile has a hydroxyphenyl and phenylamino group attached to the acetonitrile backbone, giving it potential for a wide range of applications in the production of dyes, pigments, and fine chemicals. Additionally, it has been studied for its potential biological activities, including its use in medicinal chemistry as a starting material for the synthesis of pharmaceuticals with antitumor and antibacterial properties. Its diverse range of applications and potential biological activities make it a valuable chemical in the field of organic chemistry and drug development.

Upstream product

• 779-84-0 N-phenylsalicylaldimine 
• 64-17-5 ethanol 
• 74-90-8 hydrogen cyanide 
• 38997-00-1 2-(2-aminobenzyl)phenol 
• 61195-56-0 N³-phenyl-N²-salicylidene-benzofuran-2,3-diyldiamine 
• 90-02-8 salicylaldehyde 
• 62-53-3 aniline 
• 151-50-8 potassium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 1689-73-2 N-(p-hydroxybenzylidene)aniline 

Downstream Products

• 61158-23-4 N²-(2-benzenesulfonyloxy-benzylidene)-N³-phenyl-benzofuran-2,3-diyldiamine 
• 61195-56-0 N³-phenyl-N²-salicylidene-benzofuran-2,3-diyldiamine 
• 61158-21-2 anilino-(2-hydroxy-phenyl)-acetic acid amide 

Relevant articles and documents

Synthesis and characterization of Pd supported on methane diamine (propyl silane) functionalized Fe3O4 nanoparticles as a magnetic catalyst for synthesis of α-aminonitriles and 2-methoxy-2-phenylacetonitrile derivative via Strecker-t

Pd supported on methane diamine (propyl silane) functionalized Fe3O4 magnetic nanoparticles as an organic–inorganic hybrid heterogeneous catalyst was fabricated and characterized by FT-IR, XRD, SEM, TEM, TGA, VSM, EDX, and ICP-AES te

Cu/Ni-doped sulfated zirconium oxide immobilized on CdFe2O4 NPs: a cheap, sustainable and magnetically recyclable inorgano-catalyst for the efficient preparation of α-aminonitriles in aqueous media

Abstract: A new multifunctional bimetallic nanocatalyst was prepared by immobilization of Cu/Ni-doped sulfated zirconium oxide on magnetic cadmium ferrite (CdFe2O4@SiO2@ZrO2/SO42?/Cu/Ni) and used as an efficient recyclable catalyst for one-pot as well as stepwise preparation of α-aminonitriles under mild conditions. The magnetic nanocatalyst was characterized by FTIR, TGA, VSM, XRD, EDX, FE-SEM, and TEM analyses. Also, the surface acidity of the catalyst was measured by pyridine adsorption assay. The catalyst possesses various active sites which could catalyst a variety of aromatic and aliphatic aldehydes to the corresponding α-amionitriles under moderate to high yields in the presence of aniline. Furthermore, transformation of ketones to the desired α-amionitriles and some bis-aminonitriles was also performed by this method. The catalyst could be readily recovered from the reaction mixture and reused for several times without significant loss of activity. Graphic abstract: A general and efficient method has been developed for transformation of a variety of aliphatic, aromatic aldehydes and ketones to the corresponding α-aminonitriles using a multifunctional recyclable CdFe2O4@SiO2@ZrO2/SO42?/Cu/Ni nanocatalyst.[Figure not available: see fulltext.]

Aqueous formic acid: An efficient, inexpensive and environmentally friendly organocatalyst for three-component Strecker synthesis of α-aminonitriles and imines with excellent yields

Aqueous formic acid (37%) which is an efficient, inexpensive and environmentally friendly organocatalyst was used in the Strecker reaction to afford α-aminonitriles and imines. Reaction was carried out under mild conditions and room temperature in high yi