61169-83-3

Basic information

• Product Name: (+)-(R)-3-cyclohexylbutan-1-ol
• Synonyms: (+)-(R)-3-cyclohexylbutan-1-ol
• CAS NO: 61169-83-3
• Molecular Weight: 156.268
• Mol File: 61169-83-3.mol

Chemical Properties

• CAS DataBase Reference: (+)-(R)-3-cyclohexylbutan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(R)-3-cyclohexylbutan-1-ol(61169-83-3)
• EPA Substance Registry System: (+)-(R)-3-cyclohexylbutan-1-ol(61169-83-3)

Safety Data

• Hazardous Substances Data: 61169-83-3(Hazardous Substances Data)

Upstream product

• 131719-67-0 (E)-3-cyclohexylbut-2-en-1-ol 
• 28811-79-2 ethyl 3-cyclohexylbut-2-enoate 
• 811804-97-4 (Z)-3-cyclohexyl-2-buten-1-ol 
• 61169-81-1 (R)-2-(1Ξ,2E)-but-2-enylideneamino-3,3-dimethyl-butyric acid tert-butyl ester 
• 931-50-0 cyclohexylmagnesium bromide 
• 2031-46-1 (R)-3-phenylbutanol 

Downstream Products

• 29916-19-6 (R)-(-)-2-cyclohexylbutane 
• 131665-80-0 (+)(R)-(3-bromo-1-methyl-propyl)-cyclohexane 

Relevant articles and documents

Construction of Contiguous Quaternary and Tertiary Carbon Centres via the Asymmetric Michael Reaction

Michael reactions of chiral lithioenamines of α-alkyl β-oxo esters with methyl ethylidenemalonate afforded, after hydrolysis, adducts having contiguous quaternary and tertiary carbon centres, with nearly complete enantio- and diastereo-selectivity.

Asymmetric hydrogenation of allylic alcohols using ir?N,P-Complexes

In this study, a series of γ,γ-disubstituted and β,γ-disubstituted allylic alcohols were prepared and successfully hydrogenated using suitable N,P-based Ir complexes. High yields and excellent enantioselectivities were obtained for most of the substrates studied. This investigation also revealed the effect of the acidity of the N,P?Ir-complexes on the acid-sensitive allylic alcohols. DFT ΔpKa calculations were used to explain the effect of the N,P-ligand on the acidity of the corresponding Ir-complex. The selectivity model of the reaction was used to accurately predict the absolute configuration of the hydrogenated alcohols.

Iridium-catalyzed asymmetric hydrogenation of 3,3-disubstituted allylic alcohols in ethereal solvents

Ir-phosphinomethyl-oxazoline complexes have been identified as efficient, highly enantioselective catalysts for the asymmetric hydrogenation of 3,3-disubstituted allylic alcohols and related homoallylic alcohols. In contrast to other N,P ligand complexes, which require weakly coordinating solvents, such as dichloromethane, these catalysts perform well in more ecofriendly THF or 2-MeTHF. Their synthetic potential was demonstrated with the formal total synthesis of four bisabolane sesquiterpenes. Particularly high enantioselectivity values in the asymmetric hydrogenation of 3,3-disubstituted allylic alcohols and related homoallylic alcohols have been achieved with Ir-phosphinomethyloxazoline catalysts. In contrast to other N,P-ligand complexes, which require weakly coordinating solvents, such as CH 2Cl2, these catalysts perform well in more ecofriendly THF or 2-MeTHF (see scheme; CODa =a 1,5-cyclooctadiene). Copyright