6119-70-6

Basic information

• Product Name: Quinine sulfate dihydrate
• Synonyms: Quinine sulfate fluorescence standard substance;QUININE SULPHATE 2H2O;Quinine sulfate hydrate(2:1:4);FEMA 2977;CHININI SULFAS;QUININE SULFATE;(-)-QUININE SULFATE DIHYDRATE;QUININE SULFATE DIHYDRATE
• CAS NO: 6119-70-6
• Molecular Formula: 2C₂₀H₂₄N₂O₂*2H₂O*H₂O₄S
• Molecular Weight: 782.96
• EINECS: 212-359-2
• Product Categories: Antiparasitic / Antiprotozoal / AnthelminthicVoltage-gated Ion Channels;Monovalent Ion Channels;Potassium Channel Modulators;Antiparasitic / Antiprotozoal / AnthelminthicBiochemicals and Reagents;AlkaloidAntibiotics;Antibiotics A to;Antibiotics N-SAntibiotics;Biochemicals Found in Plants;Detection;Fluorescent Probes, Labels, Particles and Stains;Nutrition Research;Spectrum of Activity;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Herb extract;API
• Mol File: 6119-70-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: ~225 °C (dec.)(lit.)
• Boiling Point: 992.5 °C at 760 mmHg
• Flash Point: 554 °C
• Appearance: Light yellow or beige to brown/Crystalline Powder
• Vapor Pressure: 1.19E-10mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: Soluble in a mixture of chloroform and absolute alcohol (2:1).
• Water Solubility: 0.12 g/100 mL (20 ºC)
• Sensitive: Light Sensitive
• Stability: Stable. Incompatible with strong oxidizing agents, alkalies, ammonia, strong bases, iodine.
• Merck: 14,8061
• BRN: 6113937
• CAS DataBase Reference: Quinine sulfate dihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Quinine sulfate dihydrate(6119-70-6)
• EPA Substance Registry System: Quinine sulfate dihydrate(6119-70-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-42/43-22-36/38
• Safety Statements: 26-45-37-24-37/39
• RIDADR: UN 2811
• WGK Germany: 3
• RTECS: VA8440000
• F: 8
• TSCA: Yes
• Hazardous Substances Data: 6119-70-6(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 6119-70-6 differently. You can refer to the following data:
1. White or almost white, crystalline powder or fine, colourless needles.
2. Quinine sulfate is odorless and has a persistent, very bitter taste. It darkens on exposure to light. Its saturated solution is neutral or alkaline to litmus.

Uses

Different sources of media describe the Uses of 6119-70-6 differently. You can refer to the following data:
1. Quinine sulfate is an antimalarial agent also used as antipyreticum and in liquids (tonic etc.).
2. Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Synthesis

Manufacture of quinine by extraction from cinchona bark and subsequent purification and synthesis to quinine sulfate

InChI:InChI=1/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m00.../s1

Synthetic route

quinine; hydrogen sulfate dihydrate (6119-70-6) → viquidil (84-55-9)

Conditions	Yield
at 60℃;
at 36℃; Behandeln mit Ameisensaeure, Essigsaeure, Propionsaeure, Buttersaeure und Milchsaeure;

quinine; hydrogen sulfate dihydrate (6119-70-6) + sulfuric acid → (R)-[(1S,2S,4S)-5-Eth-(Z)-ylidene-1-aza-bicyclo[2.2.2]oct-2-yl]-(6-methoxy-quinolin-4-yl)-methanol (16934-07-9) + α-isoquinine (16934-08-0)

Conditions	Yield
at 100℃;

Downstream Products

• 84-55-9 viquidil 
• 16934-07-9 (R)-[(1S,2S,4S)-5-Eth-(Z)-ylidene-1-aza-bicyclo[2.2.2]oct-2-yl]-(6-methoxy-quinolin-4-yl)-methanol 
• 16934-08-0 α-isoquinine