61196-83-6

Upstream product

• 1590412-47-7 3-(4-methoxyphenyl)-4,4-dimethyl-isoxazol-5(4H)-one 

Downstream Products

• 63405-36-7 5-methoxy-4-(4-methoxy-phenyl)-2,2-dimethyl-5-trifluoromethyl-2,5-dihydro-oxazole 
• 61196-82-5 2-(p-Methoxyphenyl)-5,5-dimethyl-4-(4-pyridyl)-1-pyrrolin 
• 74650-29-6 4-[(3R,5S)-5-(4-Methoxy-phenyl)-2,2-dimethyl-pyrrolidin-3-yl]-pyridine; hydrochloride 
• 61247-25-4 (4R)-2-(p-Methoxyphenyl)-5,5-dimethyl-4-(4-pyridyl)-1-pyrrolin 
• 74650-29-6 4-[(3R,5S)-5-(4-Methoxy-phenyl)-2,2-dimethyl-pyrrolidin-3-yl]-pyridine; hydrochloride 

Relevant academic research and scientific papers

Synthesis of 2H-Azirines by Iridium-Catalyzed Decarboxylative Ring Contraction of Isoxazol-5(4H)-ones

A phosphine-free iridium-catalyzed reaction of isoxazol-5(4H)-ones (isoxazolones) has been developed, and affords 2H-azirines through decarboxylation and ring contraction. This method provides an efficient and environmentally benign protocol which could replace the conventional approaches used to synthesize 2H-azirines.