61197-61-3

Basic information

• Product Name: 2-[(E)-(8-chloro-1-oxo-6-phenyl-1H-imidazo[1,2-a][1,4]benzodiazepin-2(4H)-ylidene)methyl]-4-thioxomorpholin-4-ium
• CAS NO: 61197-61-3
• Molecular Formula: C₂₂H₁₈ClN₄O₂S
• Molecular Weight: 437.9214
• Mol File: 61197-61-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(E)-(8-chloro-1-oxo-6-phenyl-1H-imidazo[1,2-a][1,4]benzodiazepin-2(4H)-ylidene)methyl]-4-thioxomorpholin-4-ium(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(E)-(8-chloro-1-oxo-6-phenyl-1H-imidazo[1,2-a][1,4]benzodiazepin-2(4H)-ylidene)methyl]-4-thioxomorpholin-4-ium(61197-61-3)
• EPA Substance Registry System: 2-[(E)-(8-chloro-1-oxo-6-phenyl-1H-imidazo[1,2-a][1,4]benzodiazepin-2(4H)-ylidene)methyl]-4-thioxomorpholin-4-ium(61197-61-3)

Safety Data

• Hazardous Substances Data: 61197-61-3(Hazardous Substances Data)

Usage

Molecular structure

Consists of a benzodiazepine core, a morpholine ring, and a thioxo group.

Molecular weight

449.93 g/mol

Inhibitor

Potent and selective inhibitor of the mitochondrial permeability transition pore (mPTP).

Role in cell death pathways

Plays a crucial role in regulating cell death through the inhibition of mPTP.

Therapeutic potential

Shows potential for use as a therapeutic agent in diseases involving mitochondrial dysfunction.

Related diseases

Neurodegenerative disorders (e.g., Alzheimer's, Parkinson's) and ischemic injury.

Unique structure and mechanism of action

Its complex structure and specific mPTP inhibition make it a promising candidate for further research and development in drug discovery.

Relevant articles and documents

1,2-Dihydro-6-phenyl-1H,4H-imidazobenzodiazepin-1-ones

Novel 1,2-dihydro-6-phenyl-1H,4H-imidazo[1,2-a][1,4]-benzodiazepin-1-ones of the formula STR1 wherein R is selected from the group consisting of hydrogen, halogen, nitro and trifluoromethyl, R1 is selected from the group consisting of hydrogen