612-84-0

Basic information

• Product Name: 3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol
• Synonyms: 3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol;3,3'-Dimethylbiphenyl-4,4'-diol;[1,1'-Biphenyl]-4,4'-diol, 3,3'-dimethyl-
• CAS NO: 612-84-0
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.2598
• Mol File: 612-84-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 351°Cat760mmHg
• Flash Point: 166.9°C
• Appearance: /
• Density: 1.163g/cm³
• CAS DataBase Reference: 3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol(612-84-0)
• EPA Substance Registry System: 3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol(612-84-0)

Safety Data

• Hazardous Substances Data: 612-84-0(Hazardous Substances Data)

Usage

General Description

3,3'-Dimethyl-1,1'-biphenyl-4,4'-diol, also known as α,α'-bis(3,5-dimethyl-4-hydroxyphenyl)-p-xylene or Tert-butylated hydroxyanisole (BHA), is a common antioxidant and preservative used in food, cosmetics, and pharmaceuticals. It is a white, crystalline powder with a slightly phenolic odor. BHA is known for its ability to prevent the oxidation of fats and oils, thereby extending the shelf life of various products. It is also used as a stabilizer in plastics, rubber, and petroleum products. While BHA has been classified as generally recognized as safe (GRAS) by the US Food and Drug Administration (FDA), some studies have raised concerns about its potential health effects, particularly in high doses.

Upstream product

• 7664-93-9 sulfuric acid 
• 95-48-7 ortho-cresol 

Downstream Products

• 612-75-9 3,3'-dimethyl-biphenyl 

Relevant articles and documents

Cerium(IV) induced oxidative coupling of simple phenols in the presence and absence of hydrogen peroxide: A comparative study of product distribution

The reaction of cerium(IV) ammonium nitrate with simple phenols (2-, 3- and 4-methylphenols) has been examined in the presence and absence of hydrogen peroxide.It has been observed that though the oxophilicity of cerium(IV) can be controlled by addition of hydrogen peroxide in the reaction medium, there is also a difference in the nature of products formed.The reaction can be used to obtain new terphenyls (3a, 3b and 3e), biphenyls (2a, and 2e), 2-hydroxy-1,9-dimethyl-7-nitro-dibenzyl-p-dioxin (4) and 3,7-dimethyl-1,9-dinitrodibenzofuran (5) in acceptable net yields.

CERIUM(IV) INDUCED HYDROXYLATION OF C-ALKYLATED HYDROCARBONS AND PHENOLS

Hydroxylation of C-alkylated phenols has benn achieved by employing cerium(IV) ammonium nitrate and hydrogen peroxyde in acetic acid medium.The yield of hydroxylation products increases markedly when 3*E-3 M solution of sodium dodecyl sulphate is added to the oxidation system.The plausible mechanism of the reaction seems to involve free radical intermediates and is influenced by hydrophobic environment.The finding are also of significance from the view point of oxidative coupling of phenols.

Synthesis of Nitrobis- and Nitrotris-cresols Using Cerium (IV) Ammonium Nitrate

Cerium (IV) ammonium nitrate (CAN) has been conveniently employed for the first time to obtain nitro substituted bis- and tris-cresols which are otherwise obtained via lengthy and difficult routes.This is the first report on one-pot and one-step synthesis of oxidatively coupled cresols.Plausible mechanism for the reaction involved has also been suggested.