6120-71-4

Usage

Uses

Used in Pharmaceutical Industry:
GUGGULSTEROLV is used as a cholesterol-lowering agent for its ability to reduce LDL cholesterol levels and increase HDL cholesterol levels, thereby promoting cardiovascular health.
Used in Nutraceutical Industry:
GUGGULSTEROLV is used as a dietary supplement for its potential health benefits in managing cholesterol levels and supporting overall cardiovascular health.
Used in Research and Development:
GUGGULSTEROLV is used as a subject of study for its anti-inflammatory and antioxidant properties, with the aim of understanding its mechanisms and potential applications in improving health outcomes.
Further research is necessary to fully comprehend the extent of Guggulsterol V's benefits and to explore its potential applications in various health-related fields.

Upstream product

• 1260-68-0 5α-cholestane-3β,5,6β-triol 3,6-diacetate 
• 1256-31-1 3β-acetoxy-5,6-epoxycholestane 
• 2701-08-8 3β-acetoxycholestane-5α,6β-diol 
• 604-35-3 Cholesteryl acetate 
• 64-17-5 ethanol 

Downstream Products

• 34408-47-4 5α-Cholestan-3β,5α,6β-triol-3-methansulfonat-6-acetat 

Relevant academic research and scientific papers

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR

Chemically diverse oxysterols were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against seven cancer (HT-29, HepG2, A549, PC3, LAMA-84, MCF-7, and SH-SY5Y) and two noncancerous cell lines (ARPE-

Synthesis of oxygenated cholesterols as structural mimics of phorbol ester-type tumor promoters

We designed several oxygenated steroids in which functional groups including a hydrophobic group are arranged analogously to those of phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA), with the aim of finding compounds with TPA-like activity, but having a different skeleton and a rigid conformation. The designed steroids, 1β,5α-dihydroxy-3β- hydroxymethylcholestan-6-one (4), 3β,5α-dihydroxycholestan-6-one (5), 3β- hydroxymethylcholestan-5α-ol-6-one (6) and 1β,3β,5α-trihydroxycholestan- 6-one (7), were synthesized. A related oxygenated steroid isolated from soft coral, cholestane-1β,3β,5α,6β-tetrol (8), was also synthesized. Among these analogs, compound 7 showed weak TPA-like activities in three biological tests: inhibition of [3H]TPA binding to protein kinase C and to cytosolic- nuclear tumor promoter-binding protein (CN-TPBP), and induction of differentiation of human promyelocytic leukemia cells (HL-60) to monocyte- like cells. On the other hand, compound 5 was found to be a specific ligand for CN-TPBP, but lacked the other TPA-like activities.

Neighbouring Group Effects. Part 2. Effect of Epoxide on the Hydrolysis of Adjacent Acetate Groups

The presence of an epoxide at the 4,5-position of a steroid accelerates the hydrolysis of an acetate group at the 3β or 6β-positions.This effect is also observed for a 1α-acetoxy-2β,3β-epoxide.A suitable fixed dipole-dipole orientation between the ester group and the adjacent polar group may be an important factor in the rate acceleration, since this neighbouring effect does not occur when a non-rigid side chain is present.Fliorine or bromine substitution at the 5α-position also enhances the rate of hydrolysis of 6β-acetoxy-group.

Lewis acid-catalyzed rearrangement of steroidal oxetanes: revision of the course of solvolysis of 3β-tosyloxy-5β-cholestan-5-ol-6-one.

The BF3-catalysed rearrangement of 6β-acetoxy-3α,5-epoxy-5α-cholestane gave the 3α,5β-diol, the 3α,10α-epoxide, and the 2α,5α-epoxide, and the product of solvolysis of 3β-tosyloxy-5β-cholestan-5-ol-6-one was identified as 3α,5-epoxy-A-homo-B-nor-5α-cholestan-4a-one.