6120-71-4

Basic information

• Product Name: GUGGULSTEROLV
• Synonyms: GUGGULSTEROLV;6β-Acetoxy-5α-cholestane-3β,5-diol;(3S,5R,6R,8S,10R,13R,17R)-3,5-dihydroxy-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl acetate
• CAS NO: 6120-71-4
• Molecular Formula: C₂₉H₅₀O₄
• Molecular Weight: 462.7049
• Mol File: 6120-71-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: GUGGULSTEROLV(CAS DataBase Reference)
• NIST Chemistry Reference: GUGGULSTEROLV(6120-71-4)
• EPA Substance Registry System: GUGGULSTEROLV(6120-71-4)

Safety Data

• Hazardous Substances Data: 6120-71-4(Hazardous Substances Data)

Usage

General Description

Guggulsterol V is a chemical compound found in the resin of the guggul tree, also known as Commiphora wightii. GUGGULSTEROLV has been studied for its potential health benefits, particularly in relation to cholesterol levels in the body. Guggulsterol V is believed to help reduce LDL cholesterol levels, also known as "bad" cholesterol, while increasing HDL cholesterol levels, known as "good" cholesterol. It may also have anti-inflammatory and antioxidant properties, making it a promising natural remedy for managing cholesterol and promoting overall cardiovascular health. Further research is needed to fully understand the mechanisms and potential applications of guggulsterol V in improving health outcomes.

Upstream product

• 1260-68-0 5α-cholestane-3β,5,6β-triol 3,6-diacetate 
• 64-17-5 ethanol 
• 604-35-3 Cholesteryl acetate 
• 1256-31-1 3β-acetoxy-5,6-epoxycholestane 
• 2701-08-8 3β-acetoxycholestane-5α,6β-diol 

Downstream Products

• 34408-47-4 5α-Cholestan-3β,5α,6β-triol-3-methansulfonat-6-acetat 

Relevant articles and documents

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR

Chemically diverse oxysterols were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against seven cancer (HT-29, HepG2, A549, PC3, LAMA-84, MCF-7, and SH-SY5Y) and two noncancerous cell lines (ARPE-

Neighbouring Group Effects. Part 2. Effect of Epoxide on the Hydrolysis of Adjacent Acetate Groups

The presence of an epoxide at the 4,5-position of a steroid accelerates the hydrolysis of an acetate group at the 3β or 6β-positions.This effect is also observed for a 1α-acetoxy-2β,3β-epoxide.A suitable fixed dipole-dipole orientation between the ester group and the adjacent polar group may be an important factor in the rate acceleration, since this neighbouring effect does not occur when a non-rigid side chain is present.Fliorine or bromine substitution at the 5α-position also enhances the rate of hydrolysis of 6β-acetoxy-group.