612040-73-0Relevant articles and documents
Synthesis of Chiral Cyclic Alcohols from Chiral Epoxides by H or N Substitution with Frontside Displacement
Da Silva Gomes, Roberto,Reddy, Karla Mahender,Corey
supporting information, p. 6310 - 6313 (2018/10/09)
Diverse examples are provided of enantioselective sequences for the transformation of cycloalkenes to either chiral trans-β-substituted cycloalkanols or chiral α-amino ketones.
Conformational effects on lipase-mediated acylations of 2-substituted cyclohexanols
Tanikaga, Rikuhei,Matsumoto, Yoshimasa,Sakaguchi, Maki,Koyama, Yohei,Ono, Kentaro
, p. 6781 - 6783 (2007/10/03)
Lipase-mediated acetylations of trans- and cis-2-substituted cyclohexanols gave the corresponding (1R)-cyclohexyl acetates and (1S)-cyclohexanols in high yields and ee, but c-4-tert-butyl-c-2-ethenyl-r-1-cyclohexanol was unreactive owing to the steric interaction between the axial OH group and the axial H atoms at the 3- and 5-positions. In the cis-isomer the OH group occupies an equatorial position to bind to the lipase, and less bulky axial alkenyl and alkynyl groups might not so much prevent acetylations than an alkyl group.