612050-97-2

Upstream product

• 612050-89-2 2-[1-[3-benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-5-(tetrahydro-pyran-2-yloxy)-3-triethylsilanyl-pent-3-enyloxy]-N,N-dimethyl-acetamide 
• 612050-88-1 (E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol 
• 612050-94-9 (2R,4R,5S,7S)-7-[(S)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-2-((R)-1-hydroxy-propyl)-5-triethylsilanyl-oxepan-4-ol 
• 612050-90-5 2-{1-[3-benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-5-hydroxy-3-triethylsilanyl-pent-3-enyloxy}-N,N-dimethyl-acetamide 
• 612050-84-7 2-{1-[3-benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-5-chloro-3-triethylsilanyl-pent-3-enyloxy}-N,N-dimethyl-acetamide 
• 612050-91-6 (1R,3S,5R,6R)-3-[(S)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-5-bromo-5-triethylsilanyl-2,7-dioxa-bicyclo[4.2.1]nonan-8-one 
• 612050-83-6 (2R,7S)-7-[(S)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-5-triethylsilanyl-2,3,6,7-tetrahydro-oxepine-2-carboxylic acid dimethylamide 
• 612050-92-7 (1R,3S,5S,6R)-3-[(S)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-5-triethylsilanyl-2,7-dioxa-bicyclo[4.2.1]nonan-8-one 
• 612050-95-0 (R)-1-{(2R,7S)-7-[(S)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-2,3,6,7-tetrahydro-oxepin-2-yl}-propan-1-ol 
• 612050-87-0 (S)-2-[(S)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-oxirane 
• 612050-96-1 (2S,7R)-2-[(S)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-7-((S)-1-bromo-propyl)-2,3,6,7-tetrahydro-oxepine 

Relevant academic research and scientific papers

Total synthesis and determination of the absolute configuration of (+)-neoisoprelaurefucin

The first total synthesis of the seven-membered ring ether marine natural product (+)-neoisoprelaurefucin (1) has been achieved employing a regioselective internal alkylation of amide 3, a novel sequence for removal of the triethylsilyl group from the resulting triethylsilyloxepene 2, and a bromoetherification of alcohol 16 as key steps. In addition, the absolute stereochemistry of the natural product was assigned.