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Usage

Uses

Used in Chemical Research:
6-Chloroindole-3-acetonitrile is used as a research compound for [application reason] in the field of chemical research. It serves as an important tool in the synthesis and study of various organic compounds, contributing to the advancement of chemical knowledge and potential applications.
Used in Pharmaceutical Industry:
6-Chloroindole-3-acetonitrile is used as an intermediate in the synthesis of pharmaceutical compounds for [application reason]. Its unique structure allows for the development of new drugs with potential therapeutic applications, such as in the treatment of various diseases and medical conditions.
Used in Material Science:
6-Chloroindole-3-acetonitrile is used as a building block in the development of new materials for [application reason] in material science. Its incorporation into the molecular structure of materials can lead to the creation of novel properties, such as improved stability, enhanced reactivity, or specific interactions with other molecules.
Used in Agricultural Applications:
6-Chloroindole-3-acetonitrile is used as a chemical component in the development of agrochemicals for [application reason] in agricultural applications. It may contribute to the creation of new pesticides, herbicides, or other products that can improve crop yield and protect plants from pests and diseases.
Used in Environmental Applications:
6-Chloroindole-3-acetonitrile is used as a component in environmental remediation processes for [application reason] in environmental applications. It may be involved in the development of new technologies or methods for the treatment of pollutants, waste management, or the improvement of environmental conditions.
Used in Analytical Chemistry:
6-Chloroindole-3-acetonitrile is used as a reference compound or analytical standard for [application reason] in analytical chemistry. It can be employed in the calibration of instruments, the development of new analytical methods, or the study of chemical reactions and interactions.

InChI:InChI=1/C10H7ClN2/c11-8-1-2-9-7(3-4-12)6-13-10(9)5-8/h1-2,5-6,13H,3H2

Upstream product

• 50517-12-9 1-(6-chloro-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 77-78-1 dimethyl sulfate 
• 17422-33-2 6-chloroindole 
• 773837-37-9 sodium cyanide 
• 703-82-2 6-chloro-1H-indole-3-carbaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 3670-19-7 2-(6-chloro-1H-indole-3-yl)ethan-1-amine 
• 1912-44-3 6-chloroindole-3-acetic acid 

Relevant academic research and scientific papers

N-skatyltryptamines-dual 5-ht6r/d2r ligands with antipsychotic and procognitive potential

A series of N-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT1A, 5-HT2A, 5-HT6, and D2 receptors. Substitution patterns resulting in affinity/activity switches were identified and studied using homology modeling. Chosen hits were screened to determine their metabolism, permeability, hepatotoxicity, and CYP inhibition. Several D2 receptor antagonists with additional 5-HT6R antagonist and agonist properties were identified. The former combination resembled known antipsychotic agents, while the latter was particularly interesting due to the fact that it has not been studied before. Selective 5-HT6R antagonists have been shown previously to produce procognitive and promnesic effects in several rodent models. Administration of 5-HT6R agonists was more ambiguous-in naive animals, it did not alter memory or produce slight amnesic effects, while in rodent models of memory impairment, they ameliorated the condition just like antagonists. Using the identified hit compounds 15 and 18, we tried to sort out the difference between ligands exhibiting the D2R antagonist function combined with 5-HT6R agonism, and mixed D2/5-HT6R antagonists in murine models of psychosis.

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst

Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.

NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES

The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.

Indolylalkylpiperidines

1-(Indolyl-3-alkyl)-3 or 4-(ureido or guanidino)-piperidines, e.g. those of the formula STR1 R= H; alkyl; free, etherified or esterified OH or SH; CF3, NO2 or NH2 m= 1-4; n= 2 or 3; X= O, S or NH acyl derivatives and salts thereof are antihypertensive agents.