61222-94-4

Upstream product

• 110-89-4 piperidine 
• 98-01-1 furfural 
• 64-17-5 ethanol 
• 614-16-4 Benzoylacetonitrile 

Downstream Products

• 128939-43-5 7-Furan-2-yl-1-oxo-5-phenyl-3-thioxo-2,3,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazole-6-carbonitrile 
• 95644-05-6 6-Amino-5-[1-furan-2-yl-meth-(E)-ylidene]-4-phenyl-2-thioxo-2,5-dihydro-pyridine-3-carbonitrile 
• 128939-49-1 7-Furan-2-yl-1,3,5-triphenyl-2-thioxo-1,2,3,7-tetrahydro-pyrano[2,3-d]imidazole-6-carbonitrile 
• 129014-33-1 (Z)-N-(2-Ethyl-phenyl)-3-furan-2-yl-2-(4-oxo-4,5-dihydro-thiazol-2-yl)-acrylamide 
• 1253801-80-7 C₂₃H₁₅NO₃ 
• 99941-43-2 7-Furan-2-yl-2-oxo-5-phenyl-3,7-dihydro-2H-pyrano[2,3-d]thiazole-6-carbonitrile 
• 99941-38-5 4-Furan-2-yl-3-methyl-1,6-diphenyl-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile 
• 1378998-64-1 C₂₀H₁₉NO₃ 

Relevant academic research and scientific papers

Activated Nitriles in Heterocyclic Synthesis: Synthesis of 6-Thiophen-2-yl and 6-Furan-2-ylthiazolopyridine Derivatives

A variety of new 6-thiophen-2-yl and 6-furan-2-ylthiazolopyridine derivatives could be prepared via the reaction of 2-functionally substituted methyl-2-thiazolin-4-one with cyanomethylenethiophen-2-yl and cyanomethylenefuran-2-yl derivatives.The st

Magnesium Halide-Catalyzed Synthesis of Oxaspiro[2.5]octenes from a Methylenecyclopropane and Acyl Cyanoalkenes

MgX2-catalyzed annulation of methylenecyclopropanes with acyl cyanoalkenes was accomplished to give oxaspiro[2.5]octenes in excellent yields. The reaction proceeded through a rare intramolecular oxa-Michael addition of Mg enolate. The oxaspiro

Dienamine-Mediated Asymmetric Inverse-Electron-Demand Hetero-Diels–Alder Reaction of Linear Deconjugated Enones: Diversity-Oriented Synthesis of 3,4-Dihydropyrans

The first organocatalytic asymmetric inverse-electron-demand Diels–Alder reaction of deconjugated enones by using a linear dienamine was explored. Electron-poor oxadienes having a cyano group were found to be suitable in this reaction. With a 20 mol-% loa

Diels-Alder reactions of acyclic α-cyano α,β-alkenones: a new approach to highly substituted cyclohexene system

The Diels-Alder reactions of a variety of acyclic α-cyano α,β-unsaturated ketones 8 have been investigated. With the assistance of boron trichloride, these compounds were found to undergo the cycloaddition readily with dienes to give the corresponding add

Regioselective synthesis of a new class of N-arylsulfonylaminated biheterocycles

A novel and efficient method for the synthesis of a new variety of novel N-arylsulfonylamino derivatives of biheterocycles by the reaction of N-cyanoaceto-arylsulphonylhydrazides with α,β-unsaturated nitriles. The synthetic potential of the method is demonstrated.

Replacement Substituent Constants for Simple Heterocycles

13C nmr absorptions are reported for the β-vinylic carbon atoms in 15 series of ethylenes bearing heterocyclic substituents.The data are used to establish the best single-parameter substituent constants, ?13, for the various heterocycles as replacements for para-substituted benzenes.Also reported are replacement dual substituent constants, including ?I and the various ?R scales needed in the Taft DSP treatment and those for F and R used in the Swain-Lupton treatment.Values of ?13, F, R, ?I, and ?Ro, respectively, for the various heterocycles as replacements for para-substituted benzenes are as follows: 2-furyl, -1.01 , 0.99, -2.51, 0.65, -0.60; 2-pyrryl, -2.53, 0.52, -5.09, -0.16, -0.62; 2-thienyl, -0.79, 2.49, -3.60, 1.82, -1.08; 3-thienyl, -0.40, 1.04, -1.57, 0.59, -0.39; 2-pyridyl, 0.88, 2.09, -0.24, 1.65, -0.45; 3-pyridyl, 0.60, 0.57, 0.63, 0.35, 0.04; and 4-pyridyl, 1.18, 1.22, 1.09, 0.92, -0.01.The DSP-NLR method of analysis is explored using electron demand parameters, ε, as determined for the vinylic side chains in para-substituted styrenes.

α,β-Unsaturated Nitriles in Heterocyclic Synthesis: The Reaction of β-(2-Furanyl)- and β-(2-Thienyl)acrylonitrile with Active Methylene Reagents

The reactions of β-(2-furanyl)- and β-(2-thienyl)acrylonitrile with a variety of active methylene reagents are described.The investigations make several new pyran and pyranodiazole derivatives accessible.