6123-64-4

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 62-53-3 aniline 
• 149-73-5 trimethyl orthoformate 
• 864131-95-3 N,N'-diphenylformamidine 

Downstream Products

• 5898-81-7 3-phenyl-1H-4-pyrazole carbonitrile 
• 54606-37-0 (5-amino-1-phenyl-1H-pyrazol-4-yl)-phenyl-methanone 
• 1044590-52-4 C₁₆H₈F₅N₃O 
• 1044590-53-5 C₁₆H₁₁Cl₂N₃O 
• 836682-64-5 3-(5-amino-4-benzoyl-pyrazol-1-yl)-N-cyclopropyl-4-methyl-benzamide 

Relevant academic research and scientific papers

Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38MAPK inhibitor RO3201195 for study in Werner syndrome cells

5-Aminopyrazol-4-yl ketones are prepared rapidly and efficiently using microwave dielectric heating from β-ketonitriles by treatment with N,N′-diphenylformamidine followed by heterocyclocondensation by irradiation with a hydrazine. The inhibitory activity of RO3201195 prepared by this methodology was confirmed in hTERT-immortalized HCA2 and WS dermal fibroblasts at 200 nM concentration, both by ELISA and immunoblot assay, and displays excellent kinase selectivity for p38α MAPK over the related stress-activated kinase JNK.

β,β-Diacyl-enamine und -enole, 9. Zur Darstellung von Aminomethylenderivaten offenkettiger CH2-acider Verbindungen

The reaction of a combination of primary or secondary aromatic or aliphatic amines with orthocarboxylic esters upon a variety of open-chain CH2-acidic molecules gives N-substituted aminoalkylidene derivatives.The method is highly recommended for methylene