61240-21-9Relevant academic research and scientific papers
A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors
Barnes, Natalie G.,Parker, Anthony W.,Ahmed Mal Ullah, Amjed A.,Ragazzon, Patricia A.,Hadfield, John A.
, (2020/08/14)
A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiproliferative activities in nanomolar concentrations. Among the compounds, 2a, 2b and 2e were the most active across three cancer cell lines. In addition, these compounds inhibited the polymerisation of tubulin in vitro more efficiently than CA-4. They caused cell cycle arrest in G2/M phase further confirming their ability to inhibit tubulin polymerisation.
Ruthenium nanoparticle-intercalated montmorillonite clay for solvent-free alkene hydrogenation reaction
Upadhyay, Praveenkumar,Srivastava, Vivek
, p. 740 - 745 (2015/02/05)
Well-characterized, ruthenium nanoparticle-intercalated montmorillonite clay was used as a catalyst in solvent-free alkene hydrogenation reactions and the corresponding products were obtained in good yields. The catalytic activity of ruthenium nanoparticle-intercalated montmorillonite clay was successfully tested with 16 different functionalized and non-functionalized alkenes. Apart from alkene reduction, the ruthenium nanoparticle-intercalated montmorillonite clay was also tested in Wittig-type reactions for obtaining dehydrobrittonin A, an important intermediate for the synthesis of brittonin A. Ruthenium nanoparticle-intercalated montmorillonite clay was found to be active in the synthesis of dehydrobrittonin A and brittonin A. The ability to recycle the catalyst nine times, together with low catalyst loading, high catalytic activity and catalytic selectivity were noteworthy advantages of the proposed protocol.
Wittig-type olefination of alcohols promoted by nickel nanoparticles: Synthesis of polymethoxylated and polyhydroxylated stilbenes
Alonso, Francisco,Riente, Paola,Yus, Miguel
supporting information; experimental part, p. 6034 - 6042 (2010/02/28)
Nickel nanoparticles were found to promote the Wittig-type olefination of primary alcohols with phosphorus ylides. The latter can be prepared from the corresponding phosphonium salts with TiBuLi or in situ generated with lithium metal. The methodology is especially efficient for the synthesis of stilbenes and is applied in the absence of any additive as a hydrogen acceptor. A new approach, to the synthesis of polymethoxylated and polyhydroxylated stilbenes, including resveratrol, DMU-212 and analogues, is presented.
Synthesis of resveratrol, DMU-212 and analogues through a novel Wittig-type olefination promoted by nickel nanoparticles
Alonso, Francisco,Riente, Paola,Yus, Miguel
body text, p. 3070 - 3073 (2009/10/04)
A novel synthesis of resveratrol, DMU-212 and analogues is presented using benzyl alcohols as phosphorus ylide partners in a one-pot Wittig-type olefination reaction promoted by nickel nanoparticles.
Sythesis of 2,2'-Diacyl-1,1'-biaryls. Regiocontrolled Protection of Ketones in Unsymmetrically Substituted 9,10-Phenanthrenequinones
Mervic, Miljenko,Ghera, Eugene
, p. 4720 - 4725 (2007/10/02)
A regiocontrolled monoketalization of unsymmetrically substituted phenanthrenequinones by use of 2,2-dimethyl-1,3-propanediol as the ketalizing reagent has been effected with the help of bromo substitution in one of the aromatic rings at the C-1 or C-8 po
