612500-27-3Relevant academic research and scientific papers
Direct peptide coupling of novel amino acid derivatives produced by rearrangement of catalytically generated ammonium ylides
Clark, J. Stephen,Middleton, Mark D.
, p. 7031 - 7034 (2007/10/03)
Protected amino acids can be prepared from substrates in which a diazo ester is aryl-tethered to an allylic amine, by catalytic intramolecular ammonium ylide generation and [2,3] rearrangement. When the aryl tether is sufficiently electron-deficient, direct coupling of the rearrangement product with a hindered amino acid ester to give a dipeptide is possible, and ammonium ylide generation, rearrangement and peptide coupling can be accomplished in a one-pot fashion.
