612527-35-2Relevant academic research and scientific papers
A study of the structure-activity relationship of GABAA-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis
Han, Dongmei,Holger Foersterling,Li, Xiaoyan,Deschamps, Jeffrey R.,Parrish, Damon,Cao, Hui,Rallapalli, Sundari,Clayton, Terry,Teng, Yun,Majumder, Samarpan,Sankar, Subramaniam,Roth, Bryan L.,Sieghart, Werner,Furtmuller, Roman,Rowlett, James K.,Weed, Michael R.,Cook, James M.
experimental part, p. 8853 - 8862 (2009/04/11)
The stable conformations of GABAA-benzodiazepine receptor bivalent ligands were determined by low temperature NMR spectroscopy and confirmed by single crystal X-ray analysis. The stable conformations in solution correlated well with those in th
Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects
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Page/Page column 50-51, (2008/06/13)
The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.
ANXIOLYTIC AGENTS WITH REDUCED SEDATIVE AND ATAXIC EFFECTS
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Page/Page column 86; 88-89, (2010/02/07)
Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.
