612546-49-3

Upstream product

• 612546-32-4 2,2-Dimethyl-propionic acid (2R,3R,4R,5R)-4-cyano-5-hydroxy-2-methyl-3-(toluene-4-sulfonylamino)-hexyl ester 
• 612546-48-2 (2S,3R,4R)-5-Hydroxy-2-((R)-1-hydroxy-ethyl)-4-methyl-3-(toluene-4-sulfonylamino)-pentanoic acid amide 
• 612546-34-6 2,2-Dimethyl-propionic acid (R)-2-[(2R,3R)-3-((R)-1-hydroxy-ethyl)-1-(toluene-4-sulfonyl)-aziridin-2-yl]-propyl ester 
• 612546-52-8 N-[(1R,2R,3R)-2-Cyano-3-hydroxy-1-((R)-2-hydroxy-1-methyl-ethyl)-butyl]-4-methyl-benzenesulfonamide 
• 612546-46-0 (R)-2-[(2R,3R)-3-((R)-1-Hydroxy-ethyl)-1-(toluene-4-sulfonyl)-aziridin-2-yl]-propan-1-ol 
• 612546-37-9 (Z)-(2R,5R)-6-Methoxymethoxy-5-methyl-hex-3-en-2-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 612546-53-9 (2S,3R,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-3-(toluene-4-sulfonylamino)-pentanoic acid amide 
• 612546-44-8 (4S,5R)-4-((1S,2S)-1-Iodo-3-methoxymethoxy-2-methyl-propyl)-5-methyl-2-trichloromethyl-4,5-dihydro-oxazole 

Relevant academic research and scientific papers

A stereoselective synthesis of a key intermediate to 1β-methylcarbapenem via aziridine ring-opening reaction

A stereocontrolled synthesis of azetidinone 3 as a key intermediate to 1β-methylcarbapenem 2 has been achieved via iodoamidation of trichloroacetimidate prepared from (Z)-olefinic allylic alcohol 6, aziridine ring-opening reaction with cyanide nucleophile and a tandem β-lactam formation.