61259-58-3Relevant academic research and scientific papers
Glucocorticoid receptor modulators
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, (2008/06/13)
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds. STR1
Reactions of Glutaconic and Homophthalic Anhydrides with Imidates, Imidoyl Chlorides, and 1-Chloroisoquinoline
Stanoeva, Elena,Haimova, Marietta,Ognyanov, Vassil
, p. 389 - 394 (2007/10/02)
Glutaconic anhydride (9) reacts with N-substituted benzimidoyl chlorides 3 to give the corresponding (Z)-3-pyrandiones 12, whereas with 1-chloroisoquinoline (4) the benzoquinolizinone 13 is obtained.The reactions of α-methylhomophthalic anhydride (10) with 3 and the imidate 7 lead to the 1(2H)-isoquinolinones 14 and 19, respectively, and with 4 to the 13-methyldibenzoquinolizinone 15.The interaction of homophthalic anhydrides 1a, b with 3 aiming at the preparation of α-condensation products is investigated.
