6126-53-0

Usage

Compound type

Cyclic ketone

Substituent group

2-Oxopropyl group attached to the cyclohexane ring

Uses

Production of fragrances and flavors, synthesis of pharmaceuticals and other organic compounds

Odor

Characteristic sweet and fruity

Applications

Flavoring agent in food products and beverages, potential use in drug development due to versatile chemical properties.

Upstream product

• 17392-08-4 2-methyl-4,5,6,7-tetrahydrobenzofuran 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 598-31-2 1-bromoacetone 
• 4749-28-4 2-nitropropene 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 26562-24-3 3-bromo-2-methoxypropene 
• 10468-40-3 cyclohexanone N-cyclohexylimine 
• 53626-84-9 2-(2-bromo-2-propen-1-yl)cyclohexanone 
• 50891-54-8 1-(1-Ethoxy-bicyclo[4.1.0]hept-7-yl)-ethanone 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 94-66-6 2-allylcyclohexan-1-one 
• 76634-95-2 3-chloro-2-(trimethylsilyloxy)prop-1-ene 
• 61759-13-5 1-(phenylselanyl)propan-2-one 
• 17851-97-7 1-tri(n-butyl)stannyloxy-1-cyclohexene 

Downstream Products

• 90642-57-2 2-methyl-4,5,6,7-tetrahydro-1H-indole 
• 95-20-5 2-methyl-1H-indole 
• 1195-14-8 2-Methylbenzothiophene 
• 13351-29-6 cis-2H-1,3,3a,4,5,6,7,7a-octahydro-7a-methyl-2-indenone 

Relevant academic research and scientific papers

Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Application to Indole Synthesis

The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system is reported. A simple combination of NH4OAc and K2CO3 under nonaerobic conditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.

Photoredox-Catalyzed Generation of Acetonyl Radical in Flow: Theoretical Investigation and Synthetic Applications

A hydrogen atom transfer (HAT) step from acetone allowed the smooth generation of acetonyl radical that was then exploited as synthon in the mild formation of C-C bonds under flow conditions. The process was promoted by aryl radicals photocatalytically generated via single-electron transfer (SET) reduction of arenediazonium salts. The mechanism has been investigated by a combined experimental and computational approach and further supported by deuterium labeling experiments.

Intramolecular Schmidt Reaction of Vinyl Azides with Cyclic Ketones

Cyclic ketones tethered with a vinyl azide group undergo a Schmidt-hydrolysis sequence to give secondary lactams bearing a ketone side chain. Secondary lactams are obtained in a regioselective manner that is not possible in a conventional Schimdt reaction. In addition to the well-documented C-2 nucleophilicity, the N nucleophilicity of vinyl azide disclosed in this work opens a new direction for reaction invention involving vinyl azides.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists

Monocyclic and bicyclic ring systems were investigated as the "core" section of a series of diphenylsulphone-containing acetic acid CRTh2 receptor antagonists. A range of potencies were observed and single-digit nanomolar potencies were obtained in both the monocyclic and bicyclic cores. Residence times for the monocyclic compounds were very short. Some of the bicyclic cores displayed better residence times. A methyl group in the northern part of the core, between the head and tail was a necessary requirement for the beginnings of long residence times. Variations of the tail substitution maximised potencies and residence times.

CANNABINOID AGONISTS

The present disclosure relates to compounds useful as agonists of the cannabinoid receptors. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment of various disorders, either alone or in combination therapy. The compounds of the invention have Formula (I).

CRTH2 MODULATORS

Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I

TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS

The present invention is related to tetrahydroindolederivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereofand to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphateoxidase (NADPH Oxidase).

Oxidative conversion of α,α-disubstituted acetamides to corresponding one-carbon-shorter ketones using hypervalent iodine (λ5) reagents in combination with tetraethylammonium bromide

(Chemical Equation Presented) α,α-Disubstituted acetamides undergo oxidative dehomologation to give one-carbon-shorter ketones when reacted with a hypervalent iodine (λ5) reagent in combination with tetraethylammonium bromide (TEAB) in various solvents. In further studies, one such combination of a hypervalent iodine (λ5) reagent, o-iodoxybenzoic acid, and TEAB has been established as a new, mild, efficient, and general method for the transformation.

Convenient and efficient Pd-catalyzed regioselective oxyfunctionalization of terminal olefins by using molecular oxygen as sole reoxidant

(Chemical Equation Presented) Just the one: The combination of palladium dichloride and N,N-dimethylacetamide (DMA) constitutes a highly efficient and reusable catalytic system, which uses molecular oxygen as the sole reoxidant for liquid-phase Wacker oxidation and acetoxylation of terminal olefins to the corresponding methyl ketones and linear allylic acetates, respectively (see scheme). 2006 Wiley-VCH Verlag GmbH Co. KGaA.

Highly efficient Wacker oxidation catalyzed by heterogeneous Pd montmorillonite under acid-free conditions

Palladium-montmorillonite was proven to be highly efficient for the Wacker oxidation of terminal olefins to the corresponding methyl ketones. The catalyst was reusable while maintaining high activity and selectivity.