61266-70-4

Basic information

• Product Name: 2-HYDROXYMETHYLOXETANE
• Synonyms: 2-HYDROXYMETHYLOXETANE;2-OXETANEMETHANOL;2,4-EPOXYBUTANOL;2-Hydroxymethyloxethane;oxetan-2-ylMethanol;2,4-Epoxybutanol 2-Oxetanemethanol
• CAS NO: 61266-70-4
• Molecular Formula: C₄H₈O₂
• Molecular Weight: 88.11
• Product Categories: Oxetanes;Simple 4-Membered Ring Compounds
• Mol File: 61266-70-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 98 °C / 15mmHg
• Flash Point: 79℃
• Appearance: Colorless to yellow/Liquid
• Density: 1,08 g/cm3
• Vapor Pressure: 0.518mmHg at 25°C
• Refractive Index: 1.4460
• Storage Temp.: 0-10°C
• Solubility: Chloroform, Methanol (Slightly)
• PKA: 14.44±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-HYDROXYMETHYLOXETANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYMETHYLOXETANE(61266-70-4)
• EPA Substance Registry System: 2-HYDROXYMETHYLOXETANE(61266-70-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 61266-70-4(Hazardous Substances Data)

Usage

Uses

2-Oxetanemethanol acts as a reagent in the metabolism-directed design of oxetane-containing arylsulfonamide derivatives as y-secretase inhibitors. Also functions as a synthetic reagent in the preparation of glycidol, a bifunctional organic compound with numerous industrial and pharmaceutical applications.

InChI:InChI=1/C4H8O2/c5-3-4-1-2-6-4/h4-5H,1-3H2

Upstream product

• 121-91-5 isophthalic acid 
• 115845-47-1 2-(1-ethoxyethoxy)methyloxetane 
• 19098-31-8 3,4-epoxy-1-butanol 

Downstream Products

• 864373-47-7 oxetane-2-carboxylic acid 
• 1165800-01-0 4-nitrophenyl oxetan-2-ylmethyl carbonate 
• 121138-00-9 2-(iodomethyl)oxetane 
• 1150888-43-9 oxetan-2-ylmethyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate 
• 1231954-94-1 N-[(2Z)-5-tert-butyl-3-isobutyl-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-(oxetan-2-ylmethoxy)benzamide 
• 1039035-67-0 ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-(oxetan-2-ylmethoxy)nicotinate 
• 115845-51-7 (oxetan-2-yl)methyl 4-methylbenzene-1-sulfonate 
• 1346262-54-1 (R)-2-{4-chloro-N-[(S)-oxetan-2-ylmethyl]phenylsulfonamido}-5,5,5-trifluoropentanamide 
• 1346262-55-2 (R)-2-{4-chloro-N-[(R)-oxetan-2-ylmethyl]phenylsulfonamido}-5,5,5-trifluoropentanamide 

Relevant articles and documents

Regio- and enantioselective cyclization of epoxy alcohols catalyzed by a [Co(III)(salen)] complex

The intramolecular cyclization of epoxy alcohols was catalyzed with excellent regio- and enantiocontrol by a [Co(III)(salen)] complex. High endo selectivity was observed for the enantioselective cyclization of terminal epoxy alcohols [Eq. (a)], while the reaction of meso substrates produced novel cyclic and bicyclic ethers in good yields and high enatiopurity. TBME = tert-butyl methyl ether.

Synthesis of Simple Oxetanes Carrying Reactive 2-Substituents

Ring-expansion of substituted epoxides using dimethyloxosulphonium methylide provides a convenient route to oxetanes carrying reactive 2-substituents that are capable of further modification.

TRANSPOSITION DES OXIRANNES-ETHANOLS PAR L'INTERMEDIAIRE D'ALCOXYETAINS. INFLUENCE DE LA CONFIGURATION DE L'OXIRANNE

The transposition of oxirane-ethanols, through alkoxytin compounds, into oxetane-2-methanols and/or oxolan-3-ols (tetrahydrofuran-3-ols) is dependent upon the oxirane configuration.Cis configuration is more suitable for the formation of the smallest ring.Steric hindrance is not sufficient enough to explain the results.