6127-98-6

Downstream Products

• 96835-74-4 4-(2-methyl-cyclohexyl)-morpholine 
• 114963-98-3 3-methyl-2-morpholinocyclohexene-1-carbothionic acid anilide 
• 114963-99-4 3-Methyl-2-morpholin-4-yl-cyclohex-1-enecarbothioic acid (4-chloro-phenyl)-amide 
• 22554-27-4 (S)-2-methylcyclohexanone 
• 22554-29-6 (R)-2-methylcyclohexanone 
• 96304-02-8 2-hydroxy-2-methylcyclohexanone 
• 114964-00-0 3-Methyl-2-morpholin-4-yl-cyclohex-1-enecarbothioic acid (4-bromo-phenyl)-amide 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOSITION CONTAINING FUSED HETERO-RING DERIVATIVE

The present invention provides a compound which indicates a histamine H4 receptor modulating activity.A compound represented by a formula (I): wherein A ring is a ring represented by the following formula: wherein R1 is substituted or unsubstituted alkyl, etc., W is -O-, etc., n is an integer of 0 to 6; X is N(R7)- or -O-; R7 is hydrogen, substituted or unsubstituted alkyl, etc.; Y is-C(R8)= or -N=; R8 is hydrogen, substituted or unsubstituted alkyl, etc.; Z is =O, =S, etc.; B ring is a ring represented by the following formula wherein R10 is each independently substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted amino; R11, R12a and R12b are each independently hydrogen or substituted or unsubstituted alkyl, etc.; p is an integer of 0 to 4, or its pharmaceutically acceptable salt, or a solvate thereof.The present invention provides a compound which indicates a histamine H4 receptor modulating activity. A compound represented by a formula (I): wherein A ring is a ring represented by the following formula: wherein R 1 is substituted or unsubstituted alkyl, etc., W is -O-, etc., n is an integer of 0 to 6; X is N(R 7 )- or -O-; R 7 is hydrogen, substituted or unsubstituted alkyl, etc.; Y is-C(R 8 )= or -N=; R 8 is hydrogen, substituted or unsubstituted alkyl, etc.; Z is =O, =S, etc.; B ring is a ring represented by the following formula wherein R 10 is each independently substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted amino; R 11 , R 12a and R 12b are each independently hydrogen or substituted or unsubstituted alkyl, etc.; p is an integer of 0 to 4, or its pharmaceutically acceptable salt, or a solvate thereof.