61273-78-7Relevant articles and documents
A convenient synthesis of Δ7,8-Morphinan-6-one and its direct oxidation to 14-hydroxy-Δ7,8-morphinan-6-one
Passarella, Daniele,Consonni, Alessandra,Giardini, Alessandra,Lesma, Giordano,Silvani, Alessandra
, p. 1981 - 1983 (2007/10/03)
Synthesis of Δ7,8-morphinan-6-one by Grewe cyclization and bromoketalization reaction as crucial steps is described. Introduction of a hydroxyl group at 14-position is demonstrated by direct oxidation with MnO2 in the presence of silica gel.