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  • 61280-75-9 Structure
  • Basic information

    1. Product Name: BOC-D-4-Nitrophe
    2. Synonyms: BOC-PNO2-D-PHE-OH;BOC-P-NITRO-D-PHENYLALANINE;BOC-P-NITRO-D-PHE-OH;BOC-4-NITRO-D-PHENYLALANINE;BOC-4-NITRO-D-PHE-OH;BOC-D-4-NITROPHE;BOC-D-4-NITROPHENYLALANINE;BOC-D-(P-NO2)PHE-OH
    3. CAS NO:61280-75-9
    4. Molecular Formula: C14H18N2O6
    5. Molecular Weight: 310.3
    6. EINECS: N/A
    7. Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Unusual Amino Acids;Boc-Amino acid series
    8. Mol File: 61280-75-9.mol
    9. Article Data: 4
  • Chemical Properties

    1. Melting Point: 120°C
    2. Boiling Point: 509.3 °C at 760 mmHg
    3. Flash Point: 261.8 °C
    4. Appearance: whaite crystalline powder
    5. Density: 1.29 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: soluble in Methanol
    9. PKA: 3.70±0.10(Predicted)
    10. BRN: 4203814
    11. CAS DataBase Reference: BOC-D-4-Nitrophe(CAS DataBase Reference)
    12. NIST Chemistry Reference: BOC-D-4-Nitrophe(61280-75-9)
    13. EPA Substance Registry System: BOC-D-4-Nitrophe(61280-75-9)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: 24/25
    4. WGK Germany: 3
    5. RTECS:
    6. F: 8
    7. HazardClass: IRRITANT
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 61280-75-9(Hazardous Substances Data)

61280-75-9 Usage

Description

BOC-D-4-Nitrophe, also known as N-Boc-p-nitro-D-phenylalanine, is a synthetic intermediate used in the chemical and pharmaceutical industries. It is the N-Boc protected form of p-Nitro-D-phenylalanine, which is an analog of Melphalan, an antineoplastic agent. BOC-D-4-Nitrophe is a white powder with specific chemical properties that make it a valuable compound in various applications.

Uses

Used in Pharmaceutical Industry:
BOC-D-4-Nitrophe is used as a synthetic intermediate for the development of pharmaceutical compounds, particularly in the synthesis of (R)-Hydroxymelphalan, an analog of Melphalan. Melphalan is an antineoplastic agent used in the treatment of various cancers, making BOC-D-4-Nitrophe a crucial component in the development of cancer-fighting drugs.
Used in Chemical Synthesis:
BOC-D-4-Nitrophe is used as a key building block in the synthesis of various chemical compounds due to its unique structure and reactivity. Its N-Boc protection group allows for selective reactions at the p-nitro group, enabling the creation of a wide range of molecules with diverse applications in the chemical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 61280-75-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,2,8 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 61280-75:
(7*6)+(6*1)+(5*2)+(4*8)+(3*0)+(2*7)+(1*5)=109
109 % 10 = 9
So 61280-75-9 is a valid CAS Registry Number.

61280-75-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • TCI America

  • (B3668)  N-(tert-Butoxycarbonyl)-4-nitro-D-phenylalanine  >98.0%(HPLC)

  • 61280-75-9

  • 1g

  • 590.00CNY

  • Detail
  • TCI America

  • (B3668)  N-(tert-Butoxycarbonyl)-4-nitro-D-phenylalanine  >98.0%(HPLC)

  • 61280-75-9

  • 5g

  • 1,990.00CNY

  • Detail
  • Alfa Aesar

  • (H61669)  N-Boc-4-nitro-D-phenylalanine, 98%   

  • 61280-75-9

  • 1g

  • 620.0CNY

  • Detail
  • Alfa Aesar

  • (H61669)  N-Boc-4-nitro-D-phenylalanine, 98%   

  • 61280-75-9

  • 5g

  • 2323.0CNY

  • Detail
  • Aldrich

  • (15174)  Boc-D-Phe(4-NO2)-OH  ≥98.0% (TLC)

  • 61280-75-9

  • 15174-5G

  • 3,437.46CNY

  • Detail

61280-75-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Boc-D-4-Nitrophe

1.2 Other means of identification

Product number -
Other names (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-nitrophenyl)propanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:61280-75-9 SDS

61280-75-9Relevant articles and documents

Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-d-alanine

Piekielna, Justyna,Gentilucci, Luca,De Marco, Rossella,Perlikowska, Renata,Adamska, Anna,Olczak, Jacek,Mazur, Marzena,Artali, Roberto,Modranka, Jakub,Janecki, Tomasz,T?mb?ly, Csaba,Janecka, Anna

, p. 6545 - 6551 (2015/02/19)

Cyclization of linear sequences is a well recognized tool in opioid peptide chemistry for generating analogs with improved bioactivities. Cyclization can be achieved through various bridging bonds between peptide ends or side-chains. In our earlier paper we have reported the synthesis and biological activity of a cyclic peptide, Tyr-c[d-Lys-Phe-Phe-Asp]NH2 (1), which can be viewed as an analog of endomorphin-2 (EM-2, Tyr-Pro-Phe-Phe-NH2). Cyclization was achieved through an amide bond between side-chains of d-Lys and Asp residues. Here, to increase rigidity of the cyclic structure, we replaced d-Lys with cis- or trans-4-aminocyclohexyl-d-alanine (d-ACAla). Two sets of analogs incorporating either Tyr or Dmt (2′,6′-dimethyltyrosine) residues in position 1 were synthesized. In the binding studies the analog incorporating Dmt and trans-d-ACAla showed high affinity for both, μ- and δ-opioid receptors (MOR and DOR, respectively) and moderate affinity for the κ-opioid receptor (KOR), while analog with Dmt and cis-d-ACAla was exceptionally MOR-selective. Conformational analyses by NMR and molecular docking studies have been performed to investigate the molecular structural features responsible for the noteworthy MOR selectivity.

Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p- nitrobenzyl)-trans-CyDTPA

Wu,Kobayashi,Sun,Yoo,Paik,Gansow,Carrasquillo,Pastan,Brechbiel

, p. 1925 - 1934 (2007/10/03)

Distinct differences in in vivo stability of the two diastereomeric C- Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.

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