612802-12-7

Basic information

• Product Name: O-p-acetoxyphenyl-2,3,4,6-tetra-O-acetyl-β-D-glucose
• Synonyms: O-p-acetoxyphenyl-2,3,4,6-tetra-O-acetyl-β-D-glucose
• CAS NO: 612802-12-7
• Molecular Weight: 482.441
• Mol File: 612802-12-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O-p-acetoxyphenyl-2,3,4,6-tetra-O-acetyl-β-D-glucose(CAS DataBase Reference)
• NIST Chemistry Reference: O-p-acetoxyphenyl-2,3,4,6-tetra-O-acetyl-β-D-glucose(612802-12-7)
• EPA Substance Registry System: O-p-acetoxyphenyl-2,3,4,6-tetra-O-acetyl-β-D-glucose(612802-12-7)

Safety Data

• Hazardous Substances Data: 612802-12-7(Hazardous Substances Data)

Upstream product

• 62983-62-4 1-O-(4′-acetylphenyl)-2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside 
• 439-03-2 2,3,4,6-tetra-O-acetyl-1-fluoro-α-D-glucopyranose 
• 604-69-3 β-D-glucose pentaacetate 
• 108-24-7 acetic anhydride 
• 497-76-7 4-hydroxyphenyl α-D-glucopyranoside 

Downstream Products

• 497-76-7 4-hydroxyphenyl α-D-glucopyranoside 

Relevant articles and documents

Chemical synthetic method for beta-arbutin

The invention provides a chemical synthetic method for beta-arbutin, which includes: 1) performing a reaction to pentaacetyl-beta-D-glucose with a 70% hydrofluoric acid pyridine solution at 10-30 DEGC to obtain tetraacetyl-alpha-fluoroglucose; 2) performing a reaction to the tetraacetyl-alpha-fluoroglucose with p-hydroxyacetophenone in a mixed solvent under catalysis of tetrabutylammonium bromidewith Ca(OH)2 being an accelerant at 20-30 DEG C to prepare p-acetylphenyl-2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside; 3) performing a reaction to the p-acetylphenyl-2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside with 40% peroxyacetic acid in an organic solvent at 5-20 DEG C to obtain p-acetoxylphenyl-2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside; 4) performing a reaction to the p-acetoxylphenyl-2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside at 15-25 DEG C in the presence of anhydrous methanol-sodium methoxide to obtain the beta-arbutin. The method is high in yield, low in cost, gentle in conditions and less in emission of waste liquid, waste gas and waste solids, and is suitable for industrial production.