612844-04-9Relevant academic research and scientific papers
Intramolecular Staudinger ligation: A powerful ring-closure method to form medium-sized lactams
David, Olivier,Meester, Wim J. N.,Bieraeugel, Hans,Schoemaker, Hans E.,Hiemstra, Henk,Van Maarseveen, Jan H.
, p. 4373 - 4375 (2003)
Efficient access to medium-sized lactams from co-amino acids that are resistant to ring-closure by traditional strategies is enabled by an intramolecular Staudinger ligation approach. An undesired premature Staudinger reaction is avoided by protecting the phosphane-containing auxiliary as a borane complex (see scheme; dabco = 1,4-diazabicyclo[2.2.2]octane).
