61294-07-3

Upstream product

• 91-56-5 indole-2,3-dione 
• 98-16-8 3-trifluoromethylaniline 

Downstream Products

• 111259-68-8 C₁₉H₁₃F₃N₂O₄S 
• 903878-06-8 1,3-dihydro-1-[3-(2-pyrrolidinylethoxy)phenyl]-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indole-2-one 

Relevant academic research and scientific papers

Preparation and antiplasmodial activity of 3',4'-dihydro-1'H-spiro(indoline-3,2'-quinolin)-2-ones

A series of 3',4'-dihydro-1'H-spiro(indoline-3,2'-quinolin)-2-ones were prepared by the inverse-electron-demand aza-Diels–Alder reaction (Povarov reaction) of imines derived from isatin and substituted anilines, and the electron-rich alkenes trans-isoeuge

BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE

Compounds of general formula I: wherein R1a, R1b, R2, R3a, R3b and X are as defined herein are tyrosine kinase inhibitors and are useful for the treatment of various diseases and conditions, for examp

Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility

A series of amino analogs of 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one (1) were synthesized to improve aqueous solubility, while retaining high affinity for the human galanin Gal3 receptor. A very potent analog (9

Aminoalkoxyphenyl indolone derivatives

This invention is directed to aminoalkoxyphenyl indolone derivatives, which are ligands at the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a

AMINOALKYLPHENYL INDOLONE DERIVATIVES

This invention is directed to aminoalkylphenyl indolone derivatives, which are ligands at the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a

Aminoalkoxyphenyl indolone derivatives

This invention is directed to aminoalkoxyphenyl indolone derivatives which are ligands at the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a

Aminoalkylphenyl indolone derivatives

This invention is directed to aminoalkylphenyl indolone derivatives which are ligands at the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a p

3-Arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists

A series of 3-imino-2-indolones are the first published, high-affinity antagonists of the galanin GAL3 receptor. One example, 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one (9), was shown to have high affinity for the

Studies in spiroheterocycles: Part XI - Synthesis of novel fluorine containing 4',5'-dihydrospirothiadiazepine>-2(1H),5'-diones from isatins

Reaction of mercaptoacetic acid with fluorinated 3-aryliminoindol-2-ones, prepared in situ from fluorinated indole-2,3-diones(isatins) and fluorinated anilines, yields 3'-arylspiro-2(1H),4'-diones(I).Under similar conditions, 3-(4-phenylpyrazol-5-ylimino)indol-2-ones(II) yield a novel system 4',5'-dihydro-9'-phenylspirothiadiazepine>-2(1H),5'-dione (III). 3-(4-Phenylpyrazol-5-ylimino)indol-2-ones have been synthesized by the reaction of fluorine containing indole-2,3-diones with 3-amino-4-phenylpyrazole in abs. ethanol.The structures of the compounds have been established on the basis of elemental analyses, and IR, PMR, 19F NMR and mass spectral data.

Synthesis of 2,4'-Dioxospiro-5'-acetic Acids: X-Ray Structure of 1-Benzyl-3'-(4-chlorophenyl)-2,4'-dioxospiro-5'-acetic Acid

The title compounds have been prepared by the cyclocondensation of mercaptosuccinic acid with isatin-3-imines.The 1-benzyl derivatives have been synthesized by simultaneously reacting 1-benzylisatin, substituted anilines and mercaptosuccinic acid.The stru