613-93-4

Basic information

• Product Name: N-METHYLBENZAMIDE
• Synonyms: N-METHYLBENZAMIDE;n-methyl-benzamid;N-Methylbenzenamide;n-methylbenzenecarboxamide;N-METHYLBENZAMIDE, 99+%;Benzamide, N-methyl- (6CI,7CI,8CI,9CI);N-MethylbenzaMide, 99+% 10GR
• CAS NO: 613-93-4
• Molecular Formula: C8H9NO
• Molecular Weight: 135.16
• EINECS: 210-362-3
• Product Categories: AMIDE;Amides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 613-93-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 76-78 °C(lit.)
• Boiling Point: 167 °C11 mm Hg(lit.)
• Flash Point: 175.9 °C
• Appearance: white crystals or crystalline powder
• Density: 1.1031 (rough estimate)
• Vapor Pressure: 0.000724mmHg at 25°C
• Refractive Index: 1.5589 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: ethanol: soluble50mg/mL, clear, yellow-green
• PKA: 15.00±0.46(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLBENZAMIDE(613-93-4)
• EPA Substance Registry System: N-METHYLBENZAMIDE(613-93-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-22
• Safety Statements: 24/25
• WGK Germany: 1
• RTECS: CV5570000
• TSCA: Yes
• Hazardous Substances Data: 613-93-4(Hazardous Substances Data)

Usage

Chemical Properties

N-methylbenzamide is an off-white crystalline solid.

Uses

N-Methylbenzamide is an important pesticide intermediate. It acts as a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.

Synthesis Reference(s)

Synthetic Communications, 7, p. 549, 1977 DOI: 10.1080/00397917709409275Tetrahedron Letters, 30, p. 451, 1989 DOI: 10.1016/S0040-4039(00)95225-0

General Description

N-Methylbenzamide is a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

N-METHYLBENZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data concerning N-METHYLBENZAMIDE are not available, however, N-METHYLBENZAMIDE is probably combustible.

InChI:InChI=1/C8H9NO/c1-9-8(10)7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10)